慢性乙型肝炎患者血清白细胞介素15的检测及其意义  

The Significance of Detection of Interleukin-15 in Serum From Patients with Chronic Hepatitis B

作　　者：刘佩芝[1] 唐先梅[2] 

机构地区：[1]石河子大学医学院第一附属医院感染科,新疆石河子832002 [2]石河子大学医学院

出　　处：《医学理论与实践》2007年第9期1017-1019,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨慢性乙型肝炎患者血清中IL-15的变化规律及其意义。方法:用酶联免疫吸附法(ELISA)测定慢性乙型肝炎患者血清中IL-15的含量。结果:各组肝炎患者IL-15水平明显高于正常对照组(P<0.01),以慢性重度肝炎组水平最高。根据谷丙转氨酶的值分组,谷丙转氨酶值最高一组患者血清中IL-15的含量较其它两组均高。根据HBV DNA含量分组,各组血清IL-15的含量无明显差异。结论:IL-15可能参与了病毒性肝炎患者的肝脏炎性损伤过程,有助于慢性乙型肝炎患者的病情判断。Objective： To investigate the law and significances of change of interleukin-15 （IL-15） in serum from patients with chronic hepatitis B. Methods： The serum levels of IL-15 in patients with chronic hepatitis B（CHB） were measured by ELISA. Results： Concentrations of serum IL-15 in patients with different type of viral hepatitis were significantly higher than that in normal group（P〈0.01）. The level of IL-15 in patients with severe hepatitis was the highest among those groups. According to the value of alanine aminotransferase （ALT）, the serum IL-15 levels in the highest group were higher than that in other groups. The difference of the serum IL-15 levels was not significant between every two groups which were divided into on the concentration of HBV DNA. Conclusion： It is possible that IL-15 plays a role in liver inflammatory injury process. The detection of level of serum IL-15 is helpful to determination of the disease in patients with chronic hepatitis B.

关 键 词：白细胞介素15 乙型肝炎 

分 类 号：R512.62[医药卫生—内科学]