参芪扶正注射液对慢性肺心病患者血液流变学的影响  

Effect of Shenqi Fuzheng Zhusheye on Hemorrheology of Chronic Pulmonary Heart Disease

作　　者：张金良[1] 范少东 孟仲蔚[3] 胡鹰[3] 

机构地区：[1]金华职业技术学院医学院,浙江金华321007 [2]浙江省兰溪市中医院,浙江兰溪321100 [3]中国人民解放军浙江金华军分区干休所,浙江金华321000

出　　处：《金华职业技术学院学报》2007年第4期60-62,共3页Journal of Jinhua Polytechnic

摘　　要：目的:观察参芪扶正注射液对慢性肺原性心脏病(以下简称肺心病)患者血液流变学的影响。方法:将74例慢性肺心病急性加重期患者随机分为A、B两组。A组(36例)在常规治疗的基础上加用参芪扶正注射液,B组(38例)仅给予常规治疗。两组均连续用药2周。治疗前后对血液流变学相关指标进行检测与对比观察。结果:患者经参芪注射液治疗后血液流变学示低切与高切变率下全血黏度、血浆比黏度、红细胞聚集指数、红细胞电泳时间、红细胞比积、血小板聚集率、纤维蛋白原均有显著性下降(P<0.01或P<0.05),与B组比较亦有显著下降(P<0.05)。临床总有效率及显效率A组分别为94.5%及50.0%;B组为73.6%及26.4%。A组疗效明显优于B组(P<0.05),治疗期间未见参芪扶正注射液严重不良反应。结论:参芪扶正注射液能显著改善慢性肺心病急性加重期患者的血液流变性,是辅助治疗肺心病的一种有效、安全的药物。Objective：To observe the effect of Shenqi Fuzheng Zhusheye（SFZ） on hemorrheology of chronic pulmonary heart diseace（CPHD）.Methods： Seventy-four patients with acute exacerbation of CPHD were divided randomly into group A（36 cases） and group B（38 cases）.The group A was treated with combined therapy of SFZ and conventional medicines.The group B was treated with conventional medicines alone.There were 2 weeks for therapy course in both groups.The purameters of hemorrheology were measured before and after treatment.Results： Showed that the whole blood viscosity under low or high sheet rate,the plasma viscosity,erythrocyte aggregation index,erythrocyte electrophraphoresie time and specific volume,platelet agglutinate rate and fibrinogen in SFZ after treatment were meekly reduced（P〈0.01 or P〈0.05 respectively）,the improvement of hemorr-heology was better than of the group B（P〈0.05）,the clinical total effective rates and obvious effective rates in group A were 94.5% and 50.5% respectively,which were higher（P〈0.05） than those in group B of 73.6% and 26.4%.No serous side-effects were found in treating with SFZ.Conclusion： SFZ can improve obviously blood rheology in patients with acute exacerbation of CPHD,it is one of effective and safe drugs for supportive treatment of CPHD

关 键 词：参芪扶正注射液 血液流变学 慢性肺原性心脏病 老年 

分 类 号：R541.5[医药卫生—心血管疾病]