血清骨钙素在高转运型骨病诊断中的意义  

Serum Bone Glo-protein Level in Diagnosis of High Turnover Bone Disease

作　　者：郭虹[1] 余开惠[1] 王柏青[1] 卓红爱[1] 曹礼应[1] 韩敬[1] 余月明[1] 段建[1] 

机构地区：[1]解放军成都军区昆明总医院肾内科,云南昆明650032

出　　处：《临床军医杂志》2007年第5期647-649,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨血透病人血清骨钙素水平在高转运型骨病诊断中的意义。方法收集62例(平均年龄55.42±14.67岁)维持性血透病人一般临床资料、测定血清钙(Ca)、磷(P)、钙磷乘积(Ca×P)、碱性磷酸酶(ALP)、全段甲状旁腺素(iPTH)及骨钙素(BGP)。以iPTH>450 ng/L为标准一(A组)及iPTH>450 ng/L、BGP>8μg/L为标准二(B组)分别预测高转运型骨病。结果两组病人血清Ca、P、Ca×P及ALP无明显差异。标准一预测高转运型骨病病人占纳入病例的50.7%,其中BGP<1.5μg/L占33%。标准二预测高转运型骨病占纳入病例的38.5%。结论血透病人血清BGP及iPTH水平明显升高(P>0.01,P>0.01),血清BGP与iPTH同时用以预测高转运型骨病具有十分重要的临床意义。Objective To makc a survcy on serum bone glo protein （BGP） as a useful parameter in the diagnosis of the patients with high turnover boric disease （IITBD）. Methods Sixty-tow paticnts （ aging 55.24±14.67 years） , Who recived lortg-tcrm hemodialysis were enrolied. We ncasbred the level of serum calcium, phosphatc, ALP, intact parathyroid hormone （iPTH） and BCI）, The scrum iPTH level over 450 pg/ml was the eritcrion for the diagnosis of HTBD （ Group A） , and the serum iPTH level over 450 pg/ml and the BGP level over 8 ng/ml acted as the other criterion for the diagnosis of iPTH） （ Croup B）. Results The levels of scram calcium, phosphate, ALl） and calcium-phosphorus product were not significantly diffcrent between Group A and B. Thc patients with the serum iPTH level over 450 pg/ml accountcd for 50.7% , and thosc with the serum iPTH level over 450 pg/ml and the serum BGP levels over 8 ng/ml accounted for 38.5%, Conclusion The serum BGP and iPTH levels arc higher than normal in both of the two groups of the patients （P 〈 0.01 , P 〈 0.01 ）. It is deemed that the serum BGP and iPTH serve as useful parameters in the diagnosis of HTBD,

关 键 词：血液透析 高转运型骨病 骨钙素 

分 类 号：R459.5[医药卫生—治疗学] R692.9[医药卫生—临床医学]