血小板α颗粒膜蛋白140检测在“病”与“证”的特异性联系  

A Platelet Alpha Granule Membrance Protein 140 Investigation and Its Idiosyncratic Links with “Disease” and “Syndrome”

作　　者：石志芸[1] 李晓明[1] 陈剑秋[1] 

机构地区：[1]上海医科大学附属华山医院

出　　处：《中国中医基础医学杂志》1997年第1期35-36,共2页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：应用血小板α颗粒膜蛋白１４０（ＧＭＰˉ１４０）为血小板活化指标，测定了７４例糖尿病、３６例心血管疾病、５３例肾脏疾病患者的血浆ＧＭＰˉ１４０浓度，并分别按病种及按是否有血瘀证分组比较了各组间的ＧＭＰˉ１４０测定值。结果表明：ＧＭＰˉ１４０在各疾病组患者均较正常人升高，三组间则无明显差异；而在血瘀及非血瘀证明之间则有明显差异。认为ＧＭＰˉ１４０有可能作为诊断血瘀证的一项实验室指标。Employing Platelet Alpha Granule Membrance Protein 140 (GMP 140) as indicator for platelet activation,determination has been made for the plasma's GMP 140 concentration for 74 cases of diabetes,36 cases of cardiovascular disease and 53 cases of rend disease and comparison has been made for the GMP 140 values determined respectively among the above mentioned three groups of diseases and between the group of bolld stasis syndrome and the group of non blood stasis syndrome.THe results showed that the GMP 140 values determined in the three groups of diseases are found higher than those of healthy people and the GMP 140 ualues are found no marked differences among the three groups of diseases but are found marked differences between blood stasis syndrome group and non blood stasis syndrome group.It is indicated that among the above mentioned three diseases,the increase of GMP 140 values has idiosyncratic links with neither of those diseases but is closely related to the blood stasis syndrome.The GMP 140 of thoes clinically diagnosed as blood stasis syndrome is found sharply increased while the GMP 140 of those clinically dignosed as non-bblood stasis syndrome is found considerably increased,indicating a latent blood stasis syndrome. It is concluded that GMP 140 may be chosen as a laboratory indicator to diagnose the blood stasis syndrome.

关 键 词：血小板 Α颗粒膜蛋白 

分 类 号：R241.3[医药卫生—中医诊断学]