参芪提取物对闭合性脑外伤作用的试验研究  

The Experimental Study of Shenqi Extraction on Craniocerebral Injury

作　　者：李宝春[1] 

机构地区：[1]安徽科技学院动物科学学院,安徽凤阳233100

出　　处：《中国实验方剂学杂志》2007年第9期41-43,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察参芪提取物(SQE)对闭合性脑外伤的作用。方法:选用昆明种小鼠,随机分成模型组、脑复康(NFK)组(0.24 g.kg-1)、参芪提取物(SQE)高、中、低剂量组(0.282,0.141,0.071 g.kg-1,按公斤体重计,相当于人用量的20,10,5倍),并设正常组。采用自由落体法复制闭合性脑外伤小鼠模型,分别于造模后8,24 h测定耐缺氧时间、脑组织含水量、脑指数和血脑屏障(BBB)通透性。结果:参芪提取物能明显降低闭合性脑外伤模型小鼠脑组织含水量、脑指数和血脑屏障通透性,与模型组比较有显著性差异(P<0.05);明显提高模型小鼠耐缺氧时间,与模型组比较有显著性差异(P<0.01)。结论:参芪提取物(SQE)对小鼠闭合性脑外伤有一定的保护作用。Objective：To observe the effects of SQE on craniocerebral injury. Methods：The mice were randondy divided into model group, NAOFUKANG （NFK） group （ 0.24 g·kg^-1 ）, three SQE groups （ 0.282,0.141,0.071 g·kg^-1 ） and control group. The model was produced by the freely falling object. Endure time of anoxia, the content of brain water, brain index, and penetrability of blood-brain-barrier （BBB） were measured. Results： SQE can obviously decrease the content of brain water, brain index, and penetrability of BBB and improve the endure time of anoxia. Conclusion： SQE has the protective effects on craniocrebraly injury.

关 键 词：参芪提取物 颅脑损伤 耐缺氧 伊文思蓝 血脑屏障 

分 类 号：R285.5[医药卫生—中药学]