保留交感神经的高选择性迷走神经切断术—动物模型的建立  

The establishment of the model of highly selective vagotomy with adrenergic preservation (HSV AP) in rat

作　　者：刘民生 高春芳[1,2] 黎介寿 邹忠寿[1,2] 

机构地区：[1]解放军一五○中心医院外五科 [2]南京军区南京总医院普通外科研究所

出　　处：《中国普通外科杂志》1997年第3期134-137,共4页China Journal of General Surgery

摘　　要：保留交感神经的高选择性迷走神经切断术（ＨＳＶＡＰ）手术方法是在高选择性迷走神经切断术（ＨＳＶ）基础上，保留胃小弯的血管，从而保留了支配胃的交感神经。６０只雄性ＳＤ大鼠随机分为三组：ＨＳＶＡＰ组、ＨＳＶ组和正常对照组（Ｃ组），每组２０只。ＨＳＶＡＰ术后胃部泌酸区交感神经分布密度与Ｃ组比较，下降不显著。去甲肾上腺素含量与Ｃ组无差别（７４５８±４０８９ｖｓ８９９６±２３５１，Ｐ＞００５）。而ＨＳＶ术后胃部泌酸区交感神经分布密度显著下降，去甲肾上腺素含量低于ＨＳＶＡＰ术后（２９３±２１４８ｖｓ７４５８±４０８９，Ｐ＜００１）。本试验证实采用保留胃小弯血管的ＨＳＶ，既可完全切断支配胃体的迷走神经，又可保留交感神经。Experimental model of HSV AP was done similarly to the technique of highly selective vagotomy (HSV), but preserved the vessels which enter to the lesser curvature of stomach, to preserve the sympathetic innervation to the organ Sixty SD rats were randomly divided into three groups: HSV AP group ( n =20), HSV group ( n= 20) and control group (group C, n =20) The results showed that the adrenergic innervation density and norepinephrine content of gastric wall in HSV AP group were similar to those in group C, and higher than those in HSV group The results confirmed that the adrenergic nerves of gastric corpus could be preserved with HSV AP

关 键 词：迷走神经切断术 交感神经系统 疾病模型 

分 类 号：R651.3[医药卫生—外科学]