盐酸阿洛司琼的合成  

Synthesis of Alosetron Hydrochloride

作　　者：赵惠清[1] 金永生[1] 赵庆杰[1] 孙青龑[1] 吴秋业[1] 

机构地区：[1]第二军医大学药学院,上海200433

出　　处：《中国医药工业杂志》2007年第9期612-613,共2页Chinese Journal of Pharmaceuticals

摘　　要：2,4-二氧代-3-哌啶甲酸甲酯钠盐脱羧后与N-甲基苯肼缩合、环合、与4-羟甲基-5-甲基咪唑缩合,最后成盐制得盐酸阿洛司琼,总收率约40%。Alosetron hydrochloride was synthesized from sodium methyl 2,4-dioxo-3-piperidinecarboxylate by hydrolytic decarboxylation condensation with N-methylphenylhydrazine, cyclization and condensation with 4-hydroxymethyl-5-methylimidazole with an overall yield of 40 %.

关 键 词：阿洛司琼 肠应激综合征 合成 

分 类 号：TQ463.5[化学工程—制药化工]