6,7-二氢-5H-环戊烯并[b]吡啶的制备  

Preparation of 6,7-Dihydro-5H-cyclopenteno[b]pyridine

作　　者：冯泽旺[1] 赵信岐[1] 

机构地区：[1]北京理工大学材料科学与工程学院

出　　处：《中国医药工业杂志》2007年第9期621-622,共2页Chinese Journal of Pharmaceuticals

摘　　要：1-氨基-2-氰基环戊烯经乙酰化、闭环和氯化反应制得4-氨基-2-氯-6,7-二氢-5H-环戊烯并[b]吡啶,再经Sandmeyer溴化和钯炭催化氢化脱卤制得6,7-二氢-5H-环戊烯并[b]吡啶,总收率为61%。6,7-Dihydro-5H-cyclopenteno [b]pyridine was prepared from 1-amino-2-cyanocyclopentene by acetylation, cyclization and chlorination to give 4-amino-2-chloro-6,7-dihydro-5H-cyclopenteno [b] pyridine, which was subjected to Sandmeyer bromination and then catalytic hydrogenated dehalogenation with an overall yield of about 61%.

关 键 词：6 7-二氢-5H-环戊烯并[b]吡啶 头孢匹罗 制备 中间体 

分 类 号：O626[理学—有机化学]