神经毒素纳米粒的制备及大鼠鼻腔给药的药动学研究  

Preparation of Neurotoxin-Ⅰ Nanoparticles and Pharmacokinetic Evaluation after Intranasal Administration in Rats

作　　者：程巧鸳[1] 李范珠[1] 

机构地区：[1]浙江中医药大学药学院药剂教研室,浙江杭州310053

出　　处：《中国医药工业杂志》2007年第9期636-637,661,共3页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金资助项目(30371781)

摘　　要：以PLGA为载体,采用复乳-溶剂挥发法制备神经毒素(1)纳米粒,考察其形态、粒径、ζ电位、包封率和载药量。并以大鼠为动物模型,评价1纳米粒溶液肌注及鼻腔给药和1溶液肌注的药动学行为。与1溶液相比,1纳米粒肌注能缩短达峰时间,升高AUC值,延长体循环时间。1纳米粒经鼻腔给药,效果优于肌注。Neurotoxin- I （1） nanoparticles were prepared by a （water-in-oil）-in water emulsion-solvent evaporation method with poly （lactic-co-glycolic acid） （PLGA） as carrier material. The shape, particle size, ζ potential, encapsulation efficiency and drug loading of the products were investigated. The pharmacokinetics in rats of 1 nanoparticles administrated by intramuscular injection and intranasal administration and 1 solution administrated by intramuscular injection were investigated, respectively. Compared with the pharmacokinetic parameters of 1 solution, the tmax of 1 nanoparticles by intramuscular injection was shortened, AUC value was increased and MRT was prolonged significantly. The therapeutic effect of 1 nanoparticles by intranasal administrated was more satisfactory than that of intramuscular injection.

关 键 词：神经毒素 纳米粒 制备 肌肉注射 鼻腔给药 药动学 

分 类 号：R944.9[医药卫生—药剂学]