骨骼肌蛋白质组学研究进展  

New developments in skeletal muscle proteomics

作　　者：蔺静[1] 柴家科[1] 

机构地区：[1]解放军总医院第一附属医院全军烧伤研究所,北京100037

出　　处：《国际病理科学与临床杂志》2007年第4期343-346,共4页Journal of International Pathology and Clinical Medicine

基　　金：国家自然科学基金(30571919)~~

摘　　要：骨骼肌组织以及肌肉蛋白为机体重要的组成部分,很多疾病以肌肉组织的特异性改变为特征。蛋白质组学技术的发展促进了骨骼肌蛋白质组学的研究,主要涉及细胞蛋白成分的整体分析,骨骼肌蛋白合成降解紊乱相关蛋白的识别与鉴定,以及衰老、肥胖和环境因素对骨骼肌的影响。蛋白质组学技术的应用,有利于发现与骨骼肌病理改变相关的诊断及预后指标,为临床治疗寻找潜在的药物靶标提供重要依据。Skeletal muscle tissues and muscle proteins are important body constituents, and a wide spectrum of various diseases is characterized by specific changes in muscle tissue, making skeletal muscle tissue interesting and perspective objects for proteomic study. In this article, we introduced the current status of proteomic technologies and described how these are being applied to the studies of skele- tal muscle, including a global analysis of cell protein components, identification of the alterations in pro- tein expression associated with processes of the unbalance between protein synthesis and degradation in skeletal muscle, and the effects of aging, obesity, and environment on skeletal muscle. The benefits of these proteomic studies should be the discovering of new diagnostic and/or prognostic biomarkers related to skeletal muscle pathological changes, and the identification of potential drug targets for the development of new therapeutic approaches.

关 键 词：蛋白质组学 骨骼肌 差异蛋白表达 

分 类 号：R341[医药卫生—基础医学]