良性前列腺增生组织中VEGF Flt-1表达及与微血管密度计数相关性研究  

The Correclate of MVD And The Expression of VEGF Flt-1 In Benign Prostatic Hyperplasia

作　　者：梁鲁南[1] 祝海洲[1] 雷学锋[1] 肖琳[1] 周荣升[1] 孙鹏[1] 

机构地区：[1]济宁医学院附属医院

出　　处：《济宁医学院学报》2007年第3期188-190,共3页Journal of Jining Medical University

摘　　要：目的探讨良性前列腺增生组织中VEGF、Flt-1表达和MVD计数的相关性。方法采用免疫组织化学S-P法,检测37例良性前列腺增生组织VEGF、Flt-1表达和MVD计数,进行等级相关性分析。结果VEGF表达与MVD计数呈正相关(P<0.05),VEGF与Flt-1表达呈正相关(P<0.05),Flt-1表达与MVD计数无相关性(P>0.05);前列腺体积与VEGF、Flt-1表达和MVD计数均无相关性(P>0.05)。结论在前列腺增生过程中VEGF与Flt-1表达呈正相关,与MVD也呈正相关。Objective To study the correclate of MVD and the expression of VEGF and Fit- 1 in benign prostatic hyperplasia （BPH）. Methods Immunohistochemical staining （S- P） was used to examine MVD and the expression of VEGF and Flt- 1 in 37 cases of BPH, Spearman rank correlation test were used for data statis- tic analysis. Results There was positive correlation betweenthe expression of VEGF and MVD Coumts,and Fit -1 expression（P 〈 0.05）, but there wasn＇t correlate between Fit- 1 expression and MVD counts, There was no correlation between the size of prostate and MVD and the expression of both VEGF and Flt- 1 in BPH（P 〉 0.05）. Conclusion In the progress of benign prostatic hyperplasia, There were positive correlate between VEGF ancl Flt- 1 and MVD.

关 键 词：良性前列腺增生 血管内皮细胞生长因子 血管内皮细胞生长因子受体-1 微血管密度 免疫组织化学 

分 类 号：R697.32[医药卫生—泌尿科学]