庆大霉素经乳汁的排泄  

Excretion of gentamycin in breastmilk

作　　者：李隆敏[1] 杨赴云[1] 赵卫红[1] 贾小芳[1] 彭名炜[1] 石月欣[1] 

机构地区：[1]北京天坛医院妇产科

出　　处：《北京医学》1997年第3期142-144,共3页Beijing Medical Journal

摘　　要：采用荧光偏振免疫法测定１４例剖宫产术后应用肌注或静点庆大霉素的产妇乳汁及血清中庆大霉素的浓度，结果表明肌注或静点庆大霉素后３～５小时，乳汁中浓度达峰值，血清中庆大霉素的浓度于给药后０．５小时达峰值。静点组均明显高于肌注组（Ｐ＜０．０５）。提示：无论肌注或静脉给庆大霉素均可经乳汁排泄，乳母不宜应用庆大霉素。即使产后已应用庆大霉素，应停药１３小时后方可哺乳。Gentamycin was given to 14 pregnant women begining on the cesarean section day througn intramuselur route(80 mg Bid) or intravenous drip(240mg in 10% glucose 500ml within 90 minutes). Gentamycin concentration in the breastmilk and serum were determined at different hours on the third postcesarean day. The peak concentration in breastmilk was reached its peak level 3～5 hours after intramusular or intravenous gentamycin was given, in serum at half an hour after intramusular or intravenous gentamycin was given. The gentamycin concentration in the intravenous drip group was higher than that of the intramuscular group(P<0 05). Whether the gentamycin was given intramusularly or intravenously, it is transferred into breastmilk. Breastfeeding women should use gentamycin cautionously. Mothers shouldn't breasteed their new born babies at least within 13 hours after gentamycin was given.

关 键 词：乳汁 血清 庆大霉素 排泄 

分 类 号：R978.12[医药卫生—药品] R174.4[医药卫生—药学]