瘦素水平与妊娠高血压疾病的关系  

Relations between serum leptin levels and hypertensive disorder complicating pregnancy

作　　者：程小尧[1] 侯艳[1] 周飞[1] 迟殊[2] 杨年[1] 陈廉[1] 

机构地区：[1]四川省人民医院妇产科,四川成都610072 [2]四川省人民医院核医学科

出　　处：《中国优生与遗传杂志》2007年第9期54-55,116,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨妊娠高血压疾病患者血清瘦素水平的变化及其与妊娠高血压疾病发病的关系。方法采用放射免疫分析法测定了30例妊娠高血压疾病患者产前、产后及脐血清瘦素水平,30例正常妊娠妇女产前、产后及脐血清瘦素水平。结果1.妊娠高血压疾病患者产前血清瘦素水平(16.01±4.01μg/L),高于正常妊娠妇女产前血清瘦素水平(12.27±5.17μg/L)。2.妊娠高血压疾病患者组,妊娠高血压组与轻度子痫前期无差异;重度子痫前期产前血清瘦素水平高于妊娠高血压组、轻度子痫前期。3.妊娠高血压疾病组重度患者产前与产后血清瘦素水平有差异,4.妊娠高血压组及轻度与正常妊娠组无差异,重度患者产后血清瘦素水平仍高于正常妊娠组。结论妊娠高血压疾病患者血清瘦素水平增高,瘦素参与了妊娠高血压疾病的发生和发展。Objectives ： To investigate the changes in serum levels of leptin in pregnant women with hypertensive disorder complicating pregnancy （HDCP） and to discuss the relationship between the serum leptin levels and HDCP. Methods： Serum leptin levels before and after delivery were measured by radio immunoassay in 30 patients with HDCP and 30 normal pregnant women. Results ： Serum levels of leptin before delivery in HDCP group （ 16.01±4. 01μg/L） were significantly higher than in normotensive women （ 12. 27±5, 17μg/L） . There was significant difference of serum leptin levels before delivery between mild group and severe group in HDCP. There was difference of serum leptin levels before delivery in severe HDCP group compared with the levels after delivery, and the levels of leptin after delivery in severe HDCP group were higher than in normotensive group. Conclusions： Serum levels of leptin increase in women with HDCP. Leptin may be involved in the onset and the development of HDCP,

关 键 词：妊娠高血压疾病 瘦素 

分 类 号：R714.246[医药卫生—妇产科学]