不同出生体重儿的甲状腺功能检测及分析  

Observation on thyroid in the various birth weight infants

作　　者：尹同进[1] 杨代秀[1] 徐巧岚[1] 叶巍岭[1] 刘立铭[1] 夏宁[1] 

机构地区：[1]江苏省盐城市第三人民医院儿科,224001

出　　处：《中国优生与遗传杂志》2007年第9期92-93,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨不同出生体重新生儿的甲状腺功能。方法将盐城市第三人民医院2003年2月~2006年12月收治的不同出生体重的新生儿120例分成4组:A组(出生体重1100g^1499g n1=30),B组(出生体重1500g^1999g n2=30),C组(出生体重2000g^2499g n3=30),D组(出生体重2500g^3750g n4=30),采用放免法测定不同出生体重新生儿出生后第1天及第10天血清FT3、FT4及TSH水平。结果各组血清FT3、FT4、TSH生后1~10天均成下降趋势,FT3、FT4的水平与出生体重成正相关,C组、D组生后第1,10天血清FT3、FT4明显高于A组、B组,B组明显高于A组,C组与D组之间差异无显著性;生后第1天TSH水平C组、D组>A组、B组,生后第10天血清TSH A组、B组>C组、D组,C组与D组之间差异无显著性。结论新生儿的甲状腺功能与出生体重成正相关,出生体重低于1999g的新生儿存在甲状腺功能的暂时性低下。Objective： To evaluate the thyroid function in the various birth weight infants. Methods： From Feb. 2003 to Dec 2006 serum free triiodothyronine （ FT3 ）, free thyronine （ FT4 ） and thyrotropin in 120 various birth weight infants on the first and tenth days after birth were detected by radioimmunoassay , 120 new birth infants were divide into four groups according to the birth weight ： the group A （birth weight between 1000g and 1499g, n1 =30）, the group B （birth weight between 1500g and 1999g, n2 = 30）, the group C （birth weight between 2000g and 2499g, n3 =30）, the group D （birth weight between 2500g and 3750g, n4 = 30） o Results： The serum concentrations of FT3, FT4, TSH showed a declining tendency in all groups from the first day to the tenth day after birth , the serum concentrations of FT3, FT4 were significantly positive correlations with the birth weight , the serum concentrations of FT3, FT4 in both group C and group D on the first day and the tenth day were significantly higher than those in both group A and group B , and those in group B were also significantly higher than those in group A, but there were no significantly difference between group C and group D . The serum concentration of TSH on the first day after birth in group A and group B were significantly higher than those in both group A and group B , But there were no significantly difference between group A and group B. On the tenth days after birth, the serum concentration of TSH in group A and group B were significantly higher than those in group C and group D, but the serum concentrations of TSH on the first and the tenth days were no significantly difference between group C and group D. Conclusion： The thyroid function in new born infants were positive correlations with the birth weight , and the thyroid function of birth weigh less than 1999g was transiently low.

关 键 词：甲状腺功能 婴儿 出生体重 

分 类 号：R722.19[医药卫生—儿科]