甲基黄酮醇胺对豚鼠单个心室肌细胞膜钙通道电流的影响  

EFFECT OF METHYLFLAVONOLAMINE ON CALCIUM CURRENT IN SINGLE GUINEA PIG VENTRICULAR MYOCYTE

作　　者：顿文[1] 吴博威[1] 韩雅娴[2] 

机构地区：[1]山西医科大学 [2]山西医科大学第一医院

出　　处：《山西医药杂志》1997年第3期216-217,共2页Shanxi Medical Journal

摘　　要：用蛋白酶Ｅ急性分离豚鼠心室肌细胞，采用先进的膜片钳技术，观察甲基黄酮醇胺对心室肌细胞膜钙离子通道的影响，结果发现：甲基黄酮醇胺１μｍ、５０μｍ及１００μｍ剂量依赖性地抑制心室肌细胞膜钙离子电流，进而从细胞膜通道水平直接证实了甲基黄酮醇胺的钙拮抗作用。Effect of methylflavonolamine (MFA) on calcium current (I Ca ) was studied in single guinea pig ventricular myocyte using whole cell patch clamp technique.It was found that I Ca was concentration dependently inhibited by MFA.This result indicates that MFA is able to block calcium channel and has an action of calcium antagonist.

关 键 词：甲基黄酮醇 钙通道电流 心室肌细胞 

分 类 号：R972[医药卫生—药品]