基于近红外三波长的血糖检测系统研制  

A Blood Glucose Detecting System Based on Three Wavelengths

作　　者：肖君[1] 王龙[1] 骆清铭[1] 龚辉[1] 

机构地区：[1]华中科技大学生物医学光子学教育部重点实验室,武汉光电国家实验室(筹)生物医学光子学研究部,湖北武汉430074

出　　处：《光电子．激光》2007年第9期1135-1138,共4页Journal of Optoelectronics·Laser

基　　金：国家自然科学基金资助项目(90508003);教育部科学技术研究重点资助项目(重点02173)

摘　　要：研制了一套基于近红外三波长的血溏浓度检测系统,其主要由光源、斩波器、探头及锁定放大器组成,3个波长分别为1200、1350和1610nm,探头采用圆-环式设计,并将源探间距设为理论分析的最佳距离3～5mm。对不同浓度葡萄糖水溶液测量表明:吸收差值比D与葡萄糖浓度具有很好的线性相关性,其相关系数为0.972。采用偏最小二乘回归建立预测模型,其预测均方根误为17.08mg/dL,相关系数可达0.997。A system based on three-wavelength in near-infrared range was designed to detect the blood glucose concentration. The system is composed of a light source,a chopper,a detector and a lock-in amplifier. 1 200 nm,1 350 nm,1 610 nm were chosen in this system. The detector contained ring source and round photodiode. And the distance of source-detector was 3- 5 mm which is derived by theoretic analysis. The result indicated that the ratio of absorption difference D depended on the glucose level linearly,and the relative coefficient was 0. 972. When using partial least square（PLS） to predict,the root mean square error of prediction （RMSEP） was 17.08 mg/dL and the relative coefficient was 0. 997.

关 键 词：近红外三波长 葡萄糖水溶液 偏最小二乘 

分 类 号：R318.51[医药卫生—生物医学工程]