盐酸坦索罗辛的合成  

Synthesis of tamsulosin hydrochloride

作　　者：杜洪光[1] 李明[1] 左洪剑[1] 刘喜全[2] 杜振涛[2] 王树明[2] 

机构地区：[1]北京化工大学理学院,北京100029 [2]北京康倍得医药技术开发有限公司,北京100089

出　　处：《化学试剂》2007年第9期541-543,共3页Chemical Reagents

摘　　要：以对甲氧基苯基丙酮为原料,经氯磺化、氨解、羰基不对称还原胺化、还原脱苄基、氨基霍夫曼烷基化反应,最后在盐酸作用下成盐得标题化合物。通过元素分析I、R1、HNMR1、3CNMR对目标产物及中间体进行了结构表征。In this paper,the synthesis of tamsulosin hydrochloride from p-methoxyphenyl acetone was briefly reviewed.The starting material was chlorosulfonated with chlorosulfonic acid,and then aminolyzed by ammonia,the intermediate was reductively aminated with R-α-phenylethylamine,and then deprived of the benzyl group,followed by Holfmann amination,transformed the salt,and then obtained tamsulosin hydrochloride.All the compounds were characterized by elemental analysis,IR,^1HNMR and ^13CNMR.

关 键 词：盐酸坦索罗辛 合成 结构表征 

分 类 号：O621.3[理学—有机化学]