正戊醛仿生合成新方法  

A novel method for biomimetic synthesis of n-pentanal

作　　者：李剑利[1] 许振华[1] 郭媛[1] 韩洁[1] 史真[1] 

机构地区：[1]西北大学化学系,陕西西安710069

出　　处：《化学试剂》2007年第9期559-560,565,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(20472067);高等学校博士学科点专项科研基金资助项目(20050697003);陕西省自然科学基金(2006B14)和西北大学科学研究基金(05NW45)资助

摘　　要：模拟四氢叶酸辅酶一碳单元转移反应,通过其甲酸氧化态模型化合物苯并咪唑盐与一碳单元的受体Grignard试剂的加成-水解反应,为正戊醛的合成提出了一种仿生合成新方法,并对其反应机理和条件进行了讨论。Based on the one-carbon unit transfer reaction of tetrahydrofolate coenzymes,n-pentanal was synthesized successfully by using benzoimidazolium salt as the tetrahydrofolate coenzyme model at the formic acid oxidation level and the Grignard reagent as a nucleophile to which one carbon unit was transferred.Herewith the novel method for the preparation of n-pentanal was proposed.The condition for the synthesis of n-pentanal was studied and its reaction mechanism was discussed.

关 键 词：四氢叶酸辅酶 苯并咪唑甲基碘盐 GRIGNARD试剂 仿生合成 

分 类 号：O623.511[理学—有机化学]