抗炎髓内钉模型局部投药及其分布情况的动物实验研究  

Study on the local administration and its distribution in the model of antiinflammatory bone nail via animal experiment

作　　者：崔健[1] 吕鸿雁[1] 冯文岭[1] 

机构地区：[1]河北医科大学第三医院骨科,石家庄市050051

出　　处：《河北医药》2007年第8期790-791,共2页Hebei Medical Journal

摘　　要：目的观察用抗炎髓内钉模型导入的造影剂在羊股骨骨折及周围软组织间隙内的分布情况,为抗炎髓内钉局部投药提供一个实验依据。方法用10条活体羊股骨造骨折模型,用带侧孔的空心钛合金管做抗炎髓内钉模型,全麻下手术,把空心钛管置入羊股骨内,注入造影剂,同时摄片,观察造影剂分布。结果10例手术共摄40张X线片,全部显示造影剂在钉周、髓腔内、周围软组织间隙内分布良好,并随着造影剂注入量的增加,其分布范围在扩大。结论带侧孔的髓内钉能够有效地把液体导入骨髓腔、骨折断端、周围软组织间隙内,是一种有效的局部投药方法。Objective To observe the distribution of contrastmedium in fracture and surrounding softtissue of the caprine femoral administrated by the model of antiinflammatory bone nail, and to provide experimental evidencesfor local administration through antiinflammatory bone nail. Methods The model of bone fracture was set up with femoral bones of 10 living sheep, and the model of antiinflammatory bone nail was established by hollow titanium alligation duct with lateral apertures, operated under general anesthesia, inserting the hollow titanium alligation duct intothe caprine femoral, injecting contrast medium, shotting X-ray, at the same time, observing the distribution of the contrastmedium. Results dO X-ray pictures were shotted totally in lO operations, they all displayed the fine distribution of the constrast medium in circum-nail, camera pulpi, surrounding soft tissue, and the distribution was enlarged with the quantity of constrast medium injected. Conclusion It displayed in the animal experiment, that the bone nail with lateral apertures can effectively introduce the fluid into cavitas medullaris, broken ends of fractured bone, surrounding soft tissue, which is an effective method for local administration.

关 键 词：髓内钉 侧孔 骨折 局部投药 骨髓腔 山羊 

分 类 号：R683.42[医药卫生—骨科学]