2型糖尿病患者外周血管病变与颈动脉粥样硬化的关系  

The relationship between peripheral arterial disease and carotid atherosclerosis in type 2 diabetic patients

作　　者：卞茸文[1] 顾刘宝[1] 吕利萍[1] 仲肇舒[1] 夏晖[1] 娄青林[1] 欧阳晓俊[1] 

机构地区：[1]南京江苏省老年医学研究所糖尿病防治研究中心,210024

出　　处：《中国糖尿病杂志》2007年第8期478-480,共3页Chinese Journal of Diabetes

基　　金：江苏省卫生厅医学科技发展基金重大课题资助项目(H200213)

摘　　要：目的以踝肱指数(ABI)和颈动脉内中膜厚度(IMT)为主要研究参数,探讨2型糖尿病(T2DM)患者外周血管病变(PAD)与颈动脉粥样硬化之间的关系。方法观察对象分为两组:(1)糖尿病合并PAD组(PAD组),59例;(2)糖尿病无PAD组,72例。比较两组IMT及颈动脉超声检测参数;并对ABI和IMT进行相关性分析。结果两组颈动脉斑块发生率相近(74.6%vs66.7%)。与无PAD组相比,PAD组IMT值较高,颈总动脉阻力指数升高,舒张期最大峰值流速及血流量显著下降。ABI与IMT呈显著负相关(r=-0.337,P<0.01)。结论(1)糖尿病合并PAD患者,其颈动脉粥样硬化病变的程度重于糖尿病无PAD者,(2)糖尿病患者的IMT与ABI存在负相关。　Objective To investigate the relationship between peripheral arterial disease and carotid atherosclerosis in type 2 diabetic patients.Method 131 individuals with type 2 diabetes were divided into two groups by the value of ankle-brachial index（ABI〈0.9,n=59,PAD;and ABI≥0.9,n=72,non-PAD）.Carotid intima-media thickness（IMT） and blood flow velocity in the carotid artery were determined by B mode colorful doppler ultrasonography.Correlation analysis was conducted between ABI and IMT.Results The incidences of plaque were similar between two groups（74.6% vs 66.7%,P〉0.05）.In study of groups of PAD versus non-PAD,PAD group showed the higher mean IMT（2.02±0.99 vs 1.74±0.94,P=0.088）,increased RI and decreased VD and VF in common carotid artery.IMT value was negatively associated with ABI（r=-0.337,P〈0.01）.Conclusion 1）The carotid atherosclerosis in T2DM is more severe in PAD group than in noo-PAD group.2） IMT value in T2DM was negatively associated with ABI.

关 键 词：踝臂血压指数 颈动脉内膜中层厚度 动脉粥样硬化 

分 类 号：R587.2[医药卫生—内分泌]