极化液治疗危重病患儿应激性高血糖的效果  

Therapeutic Effect of Glucose-Insulin-Potassium Treatment on Stress Hyperglycemia in Children

作　　者：潘丹丹[1,2] 何志旭[1,2] 赵兰[1,2] 肖群[1,2] 

机构地区：[1]贵阳医学院附属医院儿科,贵州550001 [2]贵阳医学院附属医院生化科,贵州550001

出　　处：《实用儿科临床杂志》2007年第18期1386-1387,共2页Journal of Applied Clinical Pediatrics

基　　金：贵州省卫生厅科技计划项目资助(2005-138)

摘　　要：目的探讨极化液治疗儿童应激性高血糖的疗效。方法应激性高血糖患儿30例随机分成极化液治疗组和对照组,每组各15例。在综合治疗基础上,治疗组予极化液降糖,对照组仅将葡萄糖输入量严格控制在4mg/(kg.min)以下。监测二组患儿治疗前、入院8～12h、第2、3天血糖。同时应用简化小儿危重病例评分法进行病情评估。结果入院时、入院8～12h、第2、3天血糖值,治疗组分别为(20.7±5.02)、(11.98±3.13)、(7.55±1.94)、(5.12±1.04)mmol/L,对照组分别为(19.16±4.49)、(14.89±3.42)、(10.7±2.63)、(5.95±1.33)mmol/L。与入院时血糖比较,治疗组血糖下降较快;8～12h及第2天二组血糖下降比较差异有显著性意义(Pa<0.01);第3天,二组血糖下降比较差异无显著性意义(P>0.05)。二组入院时危重状态及极危重状态各分别为7和8例;第2天,治疗组3例仍为危重状态,其余转为非危重,转安率为80%;对照组尚有7例危重,2例极危重,转安率为40%,二组转安率比较差异有显著性意义(P<0.05)。第3天,治疗组均转为非危重,对照组尚有2例危重状态、1例极危重状态。二组转安率分别为100%、80%,二组比较差异无显著性意义(P>0.05)。结论应用极化液治疗儿童应激性高血糖安全有效,经济简便,利于疾病恢复。Objective To explore the effect of treatment of children＇s stress hyperglycemia with glucose-insulin-potassium.Methods Thirty children with stress hyperglycemia were randomly divided into two groups,15 cases in each group.Patients in the treated group were admi-nistered with glucose-insulin-potassium,whereas those in the control group,glucose were transfused at the speed 〈 4 mg/（kg·min）.Blood glucose concentrations before and after treatment were measured and analyzed,and the patients＇ illness conditions evaluated by using simplified pediatric critical illness scoring system.Transformation of the conditions from danger to safety was analyzed on the second day after admission to hospital.Results The blood glucose levels before and 12 h,the second day,the third day after treatment were（20.7±5.02）mmol/L,（11.98±3.13）mmol/L,（7.55±1.94）mmol/L,（5.12±1.04）mmol/L in the treated group,respectively,and（19.16±4.49）mmol/L,（14.89±3.42）mmol/L,（10.7±2.63）mmol/L,（5.95±1.33）mmol/L in the control group,respectively.The glucose concentrations decreased sooner in the treated group than that in the control group.The difference between the two groups was statistically significant 12 h and the second day after treatment（Pa〈0.01）.At the second day,tweleve out of 15 patients in the treated group were transformed from danger to safety,with only 6 out of 15 in the control group.The difference was statistically significant（P〈0.05）,with transformation in the treated group compared with that in the control group.Conclusion Glucose-insulin-potassium treatment is an effective therapy for patients with stress hyperglycemia in child

关 键 词：极化液 高血糖 应激性 儿童 

分 类 号：R720.597[医药卫生—急诊医学]