急性一氧化碳中毒患儿血清S-100β蛋白检测的意义  

Detection of Serum S-100β in Children with Acute Carbon Monoxide Poisoning and Its Clinical Significance

作　　者：曹玉红[1] 张光运[2] 张国成[1] 丁翠玲[1] 李茹英[1] 

机构地区：[1]第四军医大学西京医院儿科,西安710032 [2]第四军医大学西京医院神经内科,西安710032

出　　处：《实用儿科临床杂志》2007年第18期1398-1399,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨急性一氧化碳中毒(CO)患儿血清S-100β蛋白水平的变化及其临床意义。方法采用酶联免疫吸附试验双抗体夹心法检测28例急性CO中毒患儿(病例组)及20例健康儿童(健康对照组)血清S-100β蛋白水平,并比较不同程度中毒患儿及迟发性脑病发生组与未发生组患儿血清S-100β的差异。结果健康对照与病例组儿童血清S-100β蛋白水平分别为(0.037±0.014)和(0.517±0.346)μg/L,二组比较有显著差异(t=6.197P<0.001);重度组与中度组、中度组与轻度组患儿S-100β相比,均有显著差异(t=5.381P<0.001;t=3.067P<0.01);迟发性脑病发生组与未发生组血清S-100β蛋白水平分别为(0.943±0.155)和(0.347±0.233)μg/L,二组比较差异显著(t=6.761P<0.001)。结论检测急性CO中毒患儿血清S-100β蛋白水平,有助于评估急性期脑组织受损的严重程度及预测迟发性脑病的发生。　Objective To explore the changes serum S-100β in children with acute carbon monoxide poisoning and its clinical significance.Methods The levels of serum S-100β of 28 children with acute carbon monoxide poisoning and those of 20 healthy children were mea-sured by enzyme-linked immunosorbent assay.Results The serum S-100β levels of the study group and control group were（0.517±0.346）and（0.037±0.014）μg/L respectively,there was significant difference between two groups（t=6.197 P〈0.001）.There was significant diffe-rence in serum S-100β levels among children with different degree of toxication（t=5.381 P〈0.01;t=3.067 P〈0.01）.The levels of S-100β in children complicated with delayed encephalopathy and those without delayed encephalopathy were（0.943±0.155）and（0.347±0.233）μg/L respectively,there was significant difference（t=6.761 P〈0.001）.Conclusions Detection of serum S-100β in children with carbon monoxide poisoning contributes not only to assessing the severe degree in the acute stage,but also to predict the possibility of delayed encephalopathy.

关 键 词：一氧化碳中毒 脑病 S-100Β蛋白 

分 类 号：R725.9[医药卫生—儿科]