天王补心丸中桔梗载药上行作用的初步研究  

Study on the Effect of Jiegeng Loading Drug up in Tianwang Buxin Wan

作　　者：李外[1] 周忻[1] 刘萍[1] 

机构地区：[1]中国人民解放军总医院,北京100853

出　　处：《中国中医药信息杂志》2007年第9期26-27,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然基金课题资助(30472202)

摘　　要：目的研究天王补心丸中桔梗载药上行的作用与脑、心、肺的关系。方法32只大鼠随机分成4组(每组8只):对照组、桔梗组、天王补心丸组、天王补心丸缺桔梗组,采用放射免疫法测定大鼠脑、心、肺组织中环核苷酸(cAMP、cGMP)的含量。结果各药物组肺组织中cAMP的含量升高,天王补心丸与天王补心丸缺桔梗2组之间存在差异性。结论天王补心丸中桔梗载药上行的作用可能与肺密切相关。Objective Objective To study the relation between Jiegeng loading drug up in Tianwang Buxin Wan and brain, heart and lung. Method 32 Wister rats were randomly divided into four groups （8 rats in each group）, namely, control group, Jiegeng group, Tianwang Buxin Wan group, Tianwang Buxin Wan lacked Jiegeng group. The levels of cyclic nucleotide in the brain, heart and lung were assayed by radioimmunoassay. The levels of cAMP in the lung in every drug group were significantly increased compared with that of control group. It was significant on the level of cAMP in the lung between Tianwang Buxin Wan group and Tianwang Buxin Wan lacked Jiegeng group. Conclusion It was the lung that linked the effect of Jiegeng loading drug up in Tianwang Buxin Wan.

关 键 词：天王补心丸 桔梗 环核苷酸 大鼠 

分 类 号：R285.5[医药卫生—中药学]