载脂蛋白E基因多态性与脑梗死的相关性  

Study of the relationship between the polymorphism of apoE gene and cerebral infarction

作　　者：满晓[1] 于炳新[1] 庞在英[1] 冷振璞[1] 

机构地区：[1]山东省立医院神经内科,济南250021

出　　处：《中国行为医学科学》2007年第9期797-798,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的探讨载脂蛋白E（apoE）基因多态性与脑梗死的相关性。方法采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术,检测40例脑梗死患者以及50例健康人的apoE基因型,同时检测不同基因型患者总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、载脂蛋白A（apoA）、载脂蛋白B（apoB）水平。结果ε3/ε3为常见基因型。ε4等位基因频率脑梗死组（20%）明显高于正常对照组（6%）（P〈0.01）。apoEε4等位基因携带者总胆固醇、低密度脂蛋白、apoB水平比apoEε2、ε3携带者高（P〈0.05）。结论apoE基因多态性与脑梗死的发病有关,ε4基因可能为该病的危险因子,其发病机制可能是通过调控载脂蛋白E导致脂代谢紊乱。Objective To investigate the correlation between the apolipoprotein E （apoE） gene polymorphism and cerebral infarction. Methods The apoE gene polymorphism of 40 cases with cerebral infarction and 50 controls were detected by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）. Meanwhile the levels of TC,TG, LDL, HDL,apoA and apoB were measured. Results Genotype ε3/ε3 was the common type. The cerebral infarction patients had a higher frequency of s4 allele （20%） than that in control group （6%） （ P〈0.01 ）. The serum levels ofTC, LDL and apoB in s4 carriers were higher than in the s2 carriers and ε3 carriers（ P 〈 0.05 ）. Conclusion The polymorphisms of apolipoprotein E gene has effect on cerebral infarction. The allele ε4 is probably the risk factor of cerebral infarction, which may cause lipid metabolism disturbance by regulating apolipoprotein E.

关 键 词：载脂蛋白E 基因多态性 脑梗死 血脂 

分 类 号：R686[医药卫生—骨科学]