五羟色胺转运体多态性与强迫症患者临床症状及认知功能的关系  

Association analysis between severity of symptom, cognitive function and 5-HTT gene polymorphism in obsessive-compulsive disorder

作　　者：周云飞[1] 张亚林[2] 胡纪泽[1] 刘铁榜[1] 刘妹 吴怀安[1] 闫小华[1] 余常红[1] 赵幸福[2] 

机构地区：[1]深圳市康宁医院,深圳518003 [2]中南大学湘雅二医院精神卫生研究所 [3]深圳市人民医院

出　　处：《中国行为医学科学》2007年第9期804-806,共3页Chinese Journal of Behavioral Medical Science

基　　金：深圳市科技计划资助项目（JH200505180193A）

摘　　要：目的探讨五羟色胺转运体启动子区（5-HTTLPR）基因多态性与强迫症临床症状严重程度及认知功能之间的关系。方法对91例强迫症采用聚合酶链反应扩增片断长度多态技术测定基因型,依此将强迫症分为S/S、S/L和L/L3组基因型,并分别采用耶鲁-布朗强迫量表（YBOCS）、韦氏记忆量表（WMS）、数字划销测验、威斯康星卡片分类测验（WCST）评估强迫症状严重程度、记忆、注意、执行功能。结果不同5-HTTLPR基因型强迫症的强迫思维分、强迫行为分、YBOCS总分差异无显著性（P〉0.05）除S/S基因型[（9.60±2.51）分]和L/L基因型[（9.58±2.07）分]的再生分显著性较S/L基因型[（7.13±2.80）分]高外,3组的瞬时记忆、短时记忆、长时记忆和记忆商数等差异无显著性（P〉0.05）;3组强迫症的各阶段的净分、失误率、划对数、划错数和划漏数等差异无显著性（P〉0.05）;S/S基因型的总错误数（29.67±18.44）次、持续错误（12.00±14.89）次、非持续错误（17.67±8.34）次和总测次数（93.58±19.35）次较L/L基因型好,S/S基因型总错误数和非持续错误的成绩显著性较S/L基因型好;S/L基因型的持续错误的成绩较L/L基因型好。S/S基因型和S/L基因型强迫症的执行功能显著性较L/L基因型好。结论不同5-HTTLPR基因型强迫症的临床症状严重程度、记忆和注意差异无显著性,而S/S基因型组和S/L基因型强迫症的执行功能显著性较L/L基因型组好。Objective To explore the relationship among 5-HTTLPR gene polymorphism and severity of symptom,cognitive function in OCD. Methods 91 OCD patients were genotyped directly for the 5-HTTLPR with polymerase chain reaction techniques. Yale-Brown obsessive compulsive scale（YBOCS） ,Wechsler Memory Scale （WMS） ,Number cancellation test （NCT） and wisconsin card sorting test （WCST） were used to assessed severity of symptom, Memory,attention and executive function of OCD patients. Results There were no significant differences among S/S, S/L and L/L genetype OCD in the following items： obsession scores, compulsion scores and YBOCS total scores（P〉0.05）. Except regeneration scores in S/S （9.60 ±2.51 ） and L/L genotype group（9.58 ± 2.07 ） was significantly higher than that in S/L genotype（ 7.13 ± 2.80） , there were found no significant differences in WMS among three genotype（ P〉 0.05 ）. No significant differences were found in total score,error rate accurate cancellation,false cancellation, missed cancellation among three OCD genotype（ P 〉 0.05）. Score for total errors （29.67 ± 18.44 ） , perseverative errors （ 12.00 ± 14.89 ） , random errors （ 17.67 ± 8.34 ） , total trials （93.58 ± 19.35） in S/S genotype was significantly better than that in L/L genotype. Total errors and random errors scores in S/S genotype was significantly better than that in S/L genotype. Perseverative errors scores in S/L genotype was significantly better than that in L/L genotype. Conclusion There were no significant differences in symptom severity,memory and attention among different 5-HTTLPR genotype. Executive function in S/S,S/L genotype group was significantly better than that in L/L genotype group.

关 键 词：强迫症 临床症状 认知功能 五羟色胺转运体启动子区 

分 类 号：R686[医药卫生—骨科学]