心型脂肪酸结合蛋白与急性冠状动脉综合征关系的研究  

Research of correlation between heart-type fatty acid binding protein and acute coronary syndrome.

作　　者：董丹丹[1] 林岫芳[1] 王东伟[1] 宋芸[1] 杨欣荣 师旭亮[3] 

机构地区：[1]中山大学附属第五医院心内一科 [2]河南省鹤壁市淇县妇幼保健站妇产科 [3]河北医科大学研究生学院

出　　处：《中国医药》2007年第11期652-654,共3页China Medicine

摘　　要：目的探讨心型脂肪酸结合蛋白(H-FABP)与急性冠状动脉综合征(ACS)早期诊断、危险分层及预后的关系。方法分别测定90例ACS患者(ACS组)、20例稳定型心绞痛(SAP)患者(SAP组),及30例健康体检者(正常时照组)的血清H-FABP浓度,比较ACS组内H-FABP与肌钙蛋白(cTnT)的变化,比较ACS组中低、中、高危患者的H-FABP浓度的不同,并于4周内观察各组住院期间并发症情况及预后的情况。结果ACS组发病3h内的患者H-FABP阳性率为40%,CTnT阳性率为10%(P<0.05);发病6 h内的患者H-FABP阳性率65%,CTnT阳性率30%(P<0.05);所有样本中H-FABP阳性诊断ACS的敏感性是95.7%,CTnT阳性诊断ACS的敏感性是81.5%(P<0.05)。ACS组内低、中、高危及急性心肌梗死患者H-FABP浓度差异具有统计学意义,发生心脏意外事件患者血清H-FABP浓度均高于未发生心脏意外事件患者(P<0.01)。结论H-FABP的定量测定对ACS患者的早期诊断、危险分层及预后评估具有重要的临床价值。Objective To investigate the correlation between heart -type fatty acid binding protein （H- FABP） and the early diagnosis,risk layers and prognosis of acute coronary syndrome （ACS）. Methods Serum level of H-FABP was detected in 90 patients with ACS （ ACS group） ,20 patients with SAP （ SAP group） and 30 normal people （normal group） respectively. The changes of H-FABP and CTnT between patients with ACS were analyzed. The different concentrations of H-FABP among low-risk , medium-risk and high-risk patients with ACS were compared, and cardiac accidents within 4 weeks were observed. Results In the patients with ACS who went to hospital within 3 hours after they felt chest pain, H-FABP positive risk is 40%, CTnT positive risk is 10% （P 〈 0. 05） ; in the patients diagnosed with ACS within 6 hours when they felt chest pain, H-FABP positive risk is 65%, CTnT positive risk is 30% （P〈0. 05） ; the sensitivity of H-FABP for diagnosis of ACS is 95.7%, the sensitivity of CTnT is 81.5% （P〈0. 05）. Within the ACS group, the concentrations of H-FABP among low-risk patients,poor- risk patients,high-risk patients and AMI patients are significantly different. The concentrations of serum H-FABP in patients with cardicac accidents are higher than without cardicac accidents （ P 〈 0. 01 ） . ConclusiOn The quantitative determination of serum H-FABP is valuable for early diagnosis, Risk Stratification and prognosis of patients with ACS.

关 键 词：急性冠状动脉综合征 心型脂肪酸结合蛋白 危险分层 独立危险因素 

分 类 号：R543.3[医药卫生—心血管疾病]