抗精神病药物对胎儿影响的临床研究  

Effects of exposure to antipsychotics during pregnancy on newborns

作　　者：朱少毅[1] 蚁丽芬[1] 王汉婵[1] 

机构地区：[1]汕头大学精神卫生中心,广东汕头515063

出　　处：《中国民康医学》2007年第17期703-704,共2页Medical Journal of Chinese People’s Health

基　　金：广东省医学科学技术研究基金资助项目(A2004447)

摘　　要：目的:探讨抗精神病药物在妊娠期使用对胎儿的影响。方法:对90例孕期一直服用抗精神病药物治疗的精神分裂症患者分娩时的年龄、丈夫年龄,精神病遗传史,新生儿出生缺陷情况及与药物的关系等进行随访登记,并将资料行统计学分析。结果:本组新生儿出生缺陷率为16.67%(15例);各药物组患者孕期病情,分娩年龄,首次妊娠例数,妊娠反应及阳性遗传史均无显著性差异(P>0.05);新生儿出生缺陷率与药物剂量有关(P<0.05),氯丙嗪对胎儿的不良影响大于其他药物,新型药物影响较小。结论:抗精神病药物只要达到一定剂量,对胎儿便有致畸、致死的不良反应,建议服用抗精神病药物,尤其是氯丙嗪治疗时,应推迟妊娠或终止妊娠。Objective：To study the effects of exposure to antipsychotics during pregnancy on newborns. Methods：Data were collected and analyzed of 90 women patients who received antipsychotics persistently during pregnancy. Results ： The incidence of birth effect was 16.67% （15patients）. The maternal age, morning sickness, family history and disease severity of patients were, significantly different between different drug groups （ P 〉0. 05 ）. The ratio of newborns birth defect was related of drug dosage （ P 〈 0. 05 ） ; The effects of chlorpromazine on newborns were more harmful than other antipsycotics. Conclusions： Antipsychotics have effect on fetus, so if patients were administered antipsychotics, especially cholpromazine, should delay pregnancy or terminate pregnancy.

关 键 词：抗精神病药物 致畸 胎儿 出生缺陷 

分 类 号：R971.4[医药卫生—药品]