丙米嗪合并阿立派唑治疗难治性抑郁症的临床观察  

A clinical study on aripiprazde combined with imipramine in treatment-refractory depression

作　　者：郭华[1] 孙群星[1] 刘勇[1] 朱玉星[1] 张爱荣[1] 

机构地区：[1]河南省驻马店市精神病院,河南驻马店463000

出　　处：《中国民康医学》2007年第17期721-722,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:观察丙米嗪合并阿立派唑治疗难治性抑郁症的疗效和不良反应。方法:采用入院顺序分层随机法,将82例难治性抑郁症患者分为研究组(阿立派唑+丙米嗪)和对照组(丙米嗪+安慰剂),在治疗前、治疗后4、8w末分别用汉密尔顿抑郁量表(HAMD)、总体疗效量表(CG I)和副反应量表(TESS)评定疗效和不良反应。结果:治疗4 w后研究组HAMD总分及各因子分比治疗前明显降低,且治疗组因子分显著低于对照组;治疗后TESS评分,4 w末研究组高于对照组,8 w末两组无显著性差异。结论:丙米嗪合并阿立派唑治疗难治性抑郁症有一定的疗效。Objective： To observe the efficacy and side effects of aripiprazde combined imipramine in the treatment of treatment - refractory depression. Methods： Being used the random control study, 82 treatment - refractory depressions were divided into study group （aripiprazole and imipramimum） and control group （imipramimum and comfort）. Effects and side effects were assessed with HAMD and CGI and TESS respectively before and after 4, 8weeks treatment. Results： Compared with before treatment, the total scores of HAMD and the scores of every factor were significantly decreased after 4 - week treatment with aripiprazole and imipramimum and the score of treatment factors was significantly lower than that of control group, after 4.8weeks treatment, the scores of TESS. of The control group were lower than that the study group in 4 - week. There was no significant significantly in 8weeks. Conclusions： The study suggests that aripiprazole combined with imipramimum is effective in the treatment of treatment - refractory depression.

关 键 词：难治性抑郁症 阿立派唑 丙米嗪 

分 类 号：R971.4[医药卫生—药品] R749.41[医药卫生—药学]