门冬氨酸鸟氨酸对肿瘤化疗药物性肝损害的保护作用  

Protective Effects of Orinithine Aspartate Against Impaired Liver Function Secondary to Chemotherapy for Malignant Tumors

作　　者：李丹[1] 曾波航[1] 

机构地区：[1]广州医学院第二附属医院肿瘤科,广东广州510260

出　　处：《广州医学院学报》2007年第1期47-48,共2页Academic Journal of Guangzhou Medical College

摘　　要：目的:探讨门冬氨酸鸟氨酸对恶性肿瘤化疗药物性肝损害的保护作用。方法:收集本院肿瘤科102例患者随机分为化疗加门冬氨酸鸟氨酸护肝组(n=51)与单纯化疗组(n=51),护肝组在化疗前1d及化疗中每日静脉滴注7.5g门冬氨酸鸟氨酸,治疗期间每2周复查肝功能。结果:护肝化疗组与单纯化疗组比较,肝功能损害发生率低,分别为10.8%和29.4%(P<0.05),护肝化疗组无Ⅲ/Ⅳ度肝功能损害,经秩和检验证明两组肝功能损害程度分布上差异有统计学意义(P<0.01)。结论:化疗联合应用门冬氨酸鸟氨酸可预防并减少化疗对肝脏的损害,提高病人对治疗的耐受性。　Objective：To evaluate the protective effects of Orinithine Aspartate（OA）on impaired liver function secondary to chemotherapy for malignant tumors.Methods：102 patients with malignancy were randomized to receive chemotherapy alone,or OA-combined chemotherapy,where OA（7.5g IV drip daily）was used starting from day-1 onwards.Liver function in all patients was followed up every two weeks.Results：The rate of liver function impairment was lower in OA-combined group（10.8%）than in chemotherapy-alone group（29.4%）（χ2=6.22,P〈0.05）.No case of degree III/IV liver impairment was found in OA-combine therapy.Rank-sum test showed a significant difference in severity distribution of liver function impairment between the two groups.Conclusion：Orinithine Aspartate was proved effective in prevention and treatment of impaired liver function secondary to chemotherapy for malignancy,which may improve patient tolerability and compliance to the treatment.

关 键 词：门冬氨酸鸟氨酸 肿瘤 化疗 肝功能损害 

分 类 号：R969.2[医药卫生—药理学]