纤维蛋白原和D-二聚体联合检测在重症急性胰腺炎早期诊断中的作用  

Combination Detection of Fibrinogen and D-dimmer for Early Diagnosis of Severe Acute Pancreatitis

作　　者：曾华[1] 林向华[1] 王惠英[1] 

机构地区：[1]中山大学附属第二医院检验科,广东广州510120

出　　处：《广州医学院学报》2007年第1期49-50,共2页Academic Journal of Guangzhou Medical College

摘　　要：目的:探讨纤维蛋白原与D-二聚体在重症急性胰腺炎时的变化。方法:应用CA1500全自动血凝仪,采用凝集法测定纤维蛋白原、免疫法测定D-二聚体,共检测收入本院的63例患者,其中19例重症急性胰腺炎患者及44例轻症急性胰腺炎患者,80名健康体检者作为对照,比较三组纤维蛋白原、D-二聚体水平差异。结果:纤维蛋白原及D-二聚体对照组分别为(2.38±1.07)g/L及(75±35)μg/L,轻症急性胰腺炎组为(3.85±1.29)g/L及(660±135)μg/L,两者差异均无统计学意义(P>0.05),重症急性胰腺炎组为(6.27±1.43)g/L及(1350±420)μg/L,与对照组及轻症急性胰腺炎组比较差异均有统计学意义(P<0.01)。结论:纤维蛋白原与D-二聚体的测定在重症急性胰腺炎的早期诊断中有重要作用。　Objective：To investigate the variation of fibrinogen（FIB）and D-dimmer in acute pancreatitis patients.Methods：We detected FIB with agglutination method and D-dimmer with immune method in 19 severe acute pancreatitis patients,44 mild acute pancreatitis patients,and 80 healthy subjects as controls.The differences of FIB and D-dimmer levels in these three groups were compared.Results：The levels of FIB and D-dimmer in control group were（2.38±1.07）g/L and（75±35）μg/L respectively,whereas in mild acute pancreatitis were（3.85±1.29）g/L and（660±135）μg/L,with no difference between them（P〉0.05）;But in acute severe ancreatitis were（6.27±1.43）g/L and（1350±420）μg/L,with significant difference between severe and mild acute pancreatitis（P〈0.01）.Conclusion：The detection of FIB and D-dimmer play an important role in early diagnosis of acute pancreatitis.

关 键 词：重症急性胰腺炎 纤维蛋白原 D-二聚体 

分 类 号：R446.1[医药卫生—诊断学]