健康人和高血压、糖尿病患者动态心率血压双乘积和动态脉压分析  

Ambulatory rate-pressure product and pulse pressure in healthy,hypertensive and diabetic subjects

作　　者：王悦强[1] 赵子彦[1] 王娟[1] 李玉阳[1] 

机构地区：[1]山东省医学科学院药物研究所抗衰老研究中心

出　　处：《中国心血管病研究》2007年第9期676-678,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨健康人和高血压、糖尿病患者的动态心率血压双乘积(ARPP)和动态脉压(APP)的昼夜变化。方法正常组50例,年龄(60.0±10.3)岁;高血压组(轻、中度)58例,年龄(59.4±8.0)岁;糖尿病组(2型,未合并高血压及未接受胰岛素治疗)47例,年龄(61.0±8.5)岁。使用TM-2421动态血压仪监测记录24h血压和心率。结果余弦法分析证实,三组ARPP和APP均有明显的昼夜节律性变化(P<0.05或0.01)。高血压组和糖尿病组ARPP均值及节律调节中值明显高于正常组(P<0.01),高血压组也明显高于糖尿病组(P<0.01);高血压组APP均值及节律调节中值明显高于正常组和糖尿病组(仅调节中值)(P<0.05或0.01)。结论ARPP和APP具有昼夜节律性变化,有临床诊断高血压的参考价值,糖尿病患者在临床确诊高血压前动态血压已发生明显改变。Objective Analysis of ambulatory rate-pressure product （ARPP） and ambulatory pulse pressure （APP） in healthy,hypertensive and diabetic subjects. Methods 155 subjects. Control group （C） 50 normotensives,aged 60.0±10.3（SD） years. Hypertension group（H）, aged 59.4±8.0 years. Diabetes group, aged 61.0± 8.5 years. TM-2421 Ambulatory Blood Pressure （ABP） Monitors were used to record 24-hour ABP data. Conventional statistics and Cosinor method were used to analyze the data. Results A significant circadian rhythndcity was confirmed for both ARPP and APP in all groups （P〈0.05,P〈0.01）. ARPP means and mesor were significantly higher in H and D than that in C （P〈0.01）, and were significant higher in H than that in D also （P〈0.01）. APP means and Mesor in H were significantly higher than that in C and D （only Mesor） （P〈0.05 or 0.01）. Conclusion APP and ARPP showed circadian variations in all groups. Our results suggest that ARPP and APP are sensitive in- dices for clinical diagnosis of hypertension, and that clearly pathological changes exist in diabetic patients before they were clinically diagnosed hypertension.

关 键 词：血压监测 便携式 心率 高血压 糖尿病 

分 类 号：R544.1[医药卫生—心血管疾病] R587.1[医药卫生—内科学]