糖肾通络方对早期糖尿病肾病患者血清内皮素、心钠素的影响  

Influence of Tangshentongluo Formula on serum levels of ET and ANP in patients with early diabetic nephropathy

作　　者：徐丽梅[1] 马建伟[1] 支艳[1] 马新英[1] 胡海翔[1] 魏汉林[1] 张文龙[1] 陈宝[1] 侯杰[1] 

机构地区：[1]空军总医院,北京100036

出　　处：《北京中医药大学学报》2007年第8期571-574,共4页Journal of Beijing University of Traditional Chinese Medicine

摘　　要：目的探讨糖肾通络方治疗糖尿病肾病(DN)的疗效及机理。方法45例DN患者随机分为糖肾通络方组(25例)及苯那普利组(20例),采用中医证候积分法观察2组治疗前后的积分,采用放射免疫法检测2组治疗前后血中的内皮素(ET)、心钠素(ANP)含量,采用生化法检测血中空腹血糖(FBG)、糖化血红蛋白(HbA1c)、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)含量及尿白蛋白排泄率(UAER)。结果两组治疗后中医证候积分糖肾通络方组明显低于苯那普利组(P<0.01),临床总有效率糖肾通络方组明显优于苯那普利组(P<0.05),虽然两组血中ET、ANP和FBG、HbA1c含量及UAER均较治疗前明显下降(P<0.05,P<0.01),但糖肾通络方组下降明显优于苯那普利组(P<0.05,P<0.01),治疗后糖肾通络方组的TC、TG、LDL-C下降,HDL-C升高较苯那普利组明显(P<0.01)。结论糖肾通络方具有较好的调整血脂、血糖,尤其是改善全身症状,提高生活质量的作用;并且具有减低或阻止ANP、ET的产生和分泌,改善肾脏受损的微血管,阻止或延缓肾小球硬化病变进展,达到改善肾功能的作用。Objective To investigate the curative effect of Tangshentongluo Formula on diabetic nephropathy （DN） and the mechanism. Methods All 45 cases of DN were randomly divided into Tangshentongluo Formula group （n = 25 ） and Lotensin group （n = 20）. Before and after the treatment the integrals of 2 groups were observed by TCM syndrome-integral method. The serum levels of endothelin （ET） and atrial natriuretic peptide （ANP） were detected by radioimmunological method, and the serum contents of fasting blood glucose （ FBG）, HbAlc, total cholesterol （ TC ）, triglyeride （ TG）, high density lipoprotein-cholesterol （ HDL-C ）, low density lipoprotein-cholesterol （ LDL-C ） and urine microalbumen excretory rate （UAER） were detected by biochemical assay. Results After the treatment the integrals of TCM syndromes in Tangshentongluo Formula group were much lower than those of Lotensin group （P 〈 0.01 ）. The total effective rate of Tangshentongluo Formula group was much higher than that of Lotensin group （P 〈 0.05 ）. Although the serum contents of ET, ANP, FBG, HbA1c and UAER in 2 groups were all decreased after the treatment （ P 〈 0.05, P 〈 0.01 ）, which was, howere, more significant in Tangshentongluo Formula group （P 〈 0.05 ,P 〈 0.01 ）. The decreases of the contents of TC, TG, LDL-C and increase of HDL-C in Tangshentongluo Formula group were more significant than those in Lotensin group after the treatment （ P 〈 0.01 ）. Conclusion Tangshentongluo Formula has better effects of regulating blood lipid and sugar, relieving general symptoms and improving the living quality. It also can reduce or arrest the secretion of ET and ANP, recover the impaired nephric capillary vessels, and to arrest or postpone glomerular sclerosis to promote renal function.

关 键 词：糖肾通络方 糖尿病肾病 内皮素 心钠素 尿微量白蛋白排泄率 肾功能 

分 类 号：R269.925[医药卫生—中西医结合]