^(99m)Tc(CO)_3-MECHDTC配合物的制备及其生物分布研究  

PREPARATION AND BIODISTRIBUTION IN MICE OF THE ^(99m)Tc(CO)_3-MECHDTC COMPLEX

作　　者：张俊波[1] 任佳蕾[1] 林艳[1] 王学斌[1] 

机构地区：[1]北京师范大学化学学院放射性药物教育部重点实验室,北京100875

出　　处：《北京师范大学学报（自然科学版）》2007年第4期423-426,共4页Journal of Beijing Normal University(Natural Science)

基　　金：国家自然科学基金青年基金资助项目(20201004);北京市科技新星计划资助项目(2004A20);北京市优秀人才培养基金资助项目(20042D0503101)

摘　　要：采用fac-[99mTc(CO)3(H2O)3]+与N-甲基-N-环己基氨荒酸盐(MECHDTC)在室温下发生配体交换反应制得99mTc(CO)3-MECHDTC配合物.用薄层层析(TLC)法和高效液相色谱(HPLC)法鉴定该配合物的放射化学纯度(R)大于90%.该配合物是一种体外稳定性良好的脂溶性电中性物质.99mTc(CO)3-MECHDTC配合物和99mTcN-MECHDTC配合物在小鼠体内生物分布结果表明,前者在小鼠心肌和脑中摄取量均较低且明显低于后者,说明在MECHDTC配体中并不适合引入[99mTc(CO)3]+核.The organometallic precursor fac-[^99mTc（CO）3（H2O）3]^＋ is reacted with N-methyl, N-cyclohexyl dithiocarbamate （MECHDTC） at room temperature to produce the ^99mTc（CO）3-MECHDTC complex. The radiochemical purity （RCP） of the product is over 90% as measured by thin layer chromatography （TLC） and by high performance liquid chromatography （HPLC）. No decomposition of the complex at room temperature （RT） is observed over a period of 6 h. The complex is neutral and lipophilic, and has good stability at room temperature. The biodistribution comparisons in mice of the ^99mTc（CO）3-MECHDTC complex and the ^99mTcN（MECHDTC）2 complex show that the former has a much lower heart and brain uptake as compared to that of the latter, suggesting the incorporation of the [^99mTc（CO）3]^＋ core into the MECHDTC ligand is not suitable to develop new better diagnostic agents.

关 键 词：锝-99m [^99mTc(CO)3]^+核 氨荒酸盐 生物分布 

分 类 号：TQ463.7[化学工程—制药化工]