血管钙化与高脂血症的关系及辛伐他汀的干预  

Research on Relationship between Vascular Calcification and Hyperlipidmia and Interference with Simvastatin

作　　者：杨晓玲[1] 张大军[2] 曹军[1] 李桂忠[1] 王菲[1] 徐华[1] 杨晓明[1] 

机构地区：[1]宁夏医学院病理生理教研室,银川750004 [2]宁夏医学院附属医院核医学科,银川750004

出　　处：《中国比较医学杂志》2007年第9期526-529,F0003,共5页Chinese Journal of Comparative Medicine

基　　金：宁夏医学院面上项目(2006)

摘　　要：目的探讨血管钙化和高脂血症的关系及辛伐他汀的治疗作用。方法将SD大鼠随机分为正常组、钙化组、高脂组、钙化高脂组、钙化辛伐他汀组、钙化高脂辛伐他汀等6组,6周后分别测定各组大鼠血脂水平,血管碱性磷酸酶和钙含量,并对血管进行VonKossa染色观察钙沉积。结果钙化组血管钙含量和碱性磷酸酶比正常组增高288.89%和259%,高脂组血清总胆固醇比正常组增高520.11%,高密度脂蛋白降低22%。钙化高脂组钙含量和碱性磷酸酶比钙化组增高36.49%和21.94%,血清总胆固醇比高脂组增高571.56%,高密度脂蛋白降低30%。结论辛伐他汀能减轻血管钙化的程度,高脂血症和血管钙化间互为因果关系,辛伐他汀在降低血脂的同时能减缓血管钙化的进程。Objective To explore the relationship between vascular calcification and hyperlipidmia and interfered with simvastatin. Method Thirty-six male SD rats were divided into six groups randomly： control group; vascular calcifid group; hyperlipidmia group; vascular calclfid group based on high lipid diet; vascular calcifid group therapid with simvastatin; vascular calcifid group based on high lipid diet tharopid with simvastatin. At the end of six weeks of drug administration, all rats were sacrificed. Total cholesterol and high-density lipoprotein levels in serum and alkaline phosphate activity and total calcium content in aorta were measured and calcium deposit were observed by Von Kossa stain. Results With 288.89% and 259% increase in the total Ca^2＋ content and ALP activity in aorta in vascular calcifid group than control group. With 520.11% increase in the total cholesterol and 22% decrease in the high-density lipoprotein cholesterol in serum in hyperlipidmia group than control group. With 36.49%, and 21.94% increase in the total Ca^2＋ content and ALP activity in aorta, and 571.56% increase TC, 30% decrease HDL in serum in vascular calclfid group based on high lipid diet than vascular calcifid group. Conclusion Simvastatin can alleviate vascular calcification, hyperlipidmia and vascular calcification are causes and effects each other. Simvastatin can postphone vascular calcification and reduce lipoprotein in serum at the same time.

关 键 词：血管钙化 高脂血症 辛伐他汀 

分 类 号：R543.1[医药卫生—心血管疾病]