维生素C对柯萨奇B_3病毒感染的心肌细胞的保护作用研究  

Protective effect of VC on myocardial cells infected by Coxsackie virus B 3

作　　者：张福明[1] 王相峰 张淑琴[1] 

机构地区：[1]白求恩医大第一临床学院

出　　处：《白求恩医科大学学报》1997年第4期379-380,共2页Journal of Norman Bethune University of Medical Science

摘　　要：观察维生素Ｃ对柯萨奇Ｂ３（ＣＶＢ３）病毒的复制和对病毒感染心肌细胞的影响，结果表明：维生素Ｃ（ＶｉｔＣ）对ＣＶＢ３感染的心肌细胞具有保护作用，加ＶｉｔＣ培养２４ｈ后，随时间延长，保护作用越来越明显（Ｐ＜０．０５）；实验结果还表明：ＶｉｔＣ在细胞外并无直接灭活病毒作用，而是作用于细胞，影响病毒的复制，从而使心肌细胞得到保护。In this paper,we studied the effect of VC on the reproduction of CVB 3 and the activity of myocardial cells which were infected by the viruses.The results showed that vitamine C (VC) protected myocardial cells from virus infection .The protection of VC to the cells incrased with cultured period ( P <0 05).Therefore,the mechanism of the protection was probably that VC affected virus proliferation by the cells,and the myocardial cells were prevented from virus infection.

关 键 词：维生素C 柯萨奇B3病毒 心肌细胞 克山病 心肌炎 

分 类 号：R542.210.5[医药卫生—心血管疾病] R542.305[医药卫生—内科学]