冠状动脉节段性痉挛和冠状动脉病变程度与血浆ox-LDL水平相关  

Plasma ox-LDL is positively correlated with coronary artery segmental spasm and severity of coronary atherosclerosis

作　　者：何喜民[1] 向定成[1] 何建新[1] 邱健[1] 马骏[1] 洪长江[1] 

机构地区：[1]广州军区广州总医院心血管内科,广东广州510010

出　　处：《心脏杂志》2007年第4期438-440,共3页Chinese Heart Journal

基　　金：广东省自然科学基金项目资助(No:032168)

摘　　要：目的探讨血浆氧化型低密度脂蛋白(ox-LDL)水平与冠状动脉痉挛(CAS组)及稳定型心绞痛(SAP组)患者冠状动脉病变程度之间的关系。方法CAS组(n=31):临床上具有胸痛表现,冠状动脉造影无显著狭窄并经过乙酰胆碱试验确诊的患者;SAP组(n=35):稳定的劳力型心绞痛患者;对照组(n=24),为健康体检者。3组于清晨空腹采取静脉血,采用ELISA法检测血浆ox-LDL含量,按照痉挛与非痉挛、弥漫性痉挛和节段性痉挛以及SAP患者冠脉病变范围进行分组比较其ox-LDL水平。结果SAP组血浆ox-LDL含量均高于对照组和CAS组(P<0.01),CAS组血浆ox-LDL含量高于对照组,但无统计学意义;节段性痉挛患者血浆ox-LDL水平较弥漫性痉挛患者高(P<O.O5),SAP患者中多支血管病变组的ox-LDL含量较单支血管病变显著升高(P<0.01)。结论血浆ox-LDL水平与节段性CAS和冠状动脉病变和严重程度正相关。AIM To determinate the level of plasma oxidized low-density lipoprotein （ox-LDL） in patients with coronary artery spasm （CAS） and to explore the relationship between oxidized low-density lipoprotein and coronary spasm and lesion extent in coronary artery with stable angina pectoris （SAP）. METHODS Plasma ox-LDL was measured by enzyme-linked immunosorbent assay in 90 patients who were divided into 3 groups ： CAS group （ n = 31 ）, those with chest pain but no significant coronary artery stenosis and diagnosed by acetylcholine test, SAP group （ n = 35 ）, those with stable effort angina, and healthy control group （ n = 24）. The plasma ox-LDL was compared between the groups of spasm and nonspasm, segmental spasm and diffuse spasm, single-vessel lesion and multi-vessel lesion in SAP. RESULTS The level of plasma ox-LDL was higher in patients with SAP than that in CAS patients, higher in patients with segmental spasm than that in those with diffuse spasm （ P 〈 0.05 ）, and was remarkable higher in patients with multi-vessel lesion than those with single-vessel SAP or in patients with segmental spasm, respectively （P 〈 0.01 ）. CONCLUSION Plasma ox-LDL is positively correlated with segmental CAS and the severity of coronary atherosclerosis.

关 键 词：冠状动脉痉挛 心绞痛 稳定型 氧化性低密度脂蛋白 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]