门冬氨酸洛美沙星粉针剂的制备及其含量测定  

Preparation and Quantitative Determination of Lomefloxacin Aspartate for Injection

作　　者：刘杰[1] 宁宇杉[1] 闫燕 李萍[1] 朱建芬 

机构地区：[1]青岛市市立医院药剂科,青岛266011 [2]青岛市食品药品监督管理局,青岛266001

出　　处：《科学技术与工程》2007年第19期4855-4858,共4页Science Technology and Engineering

摘　　要：通过筛选赋形剂的种类和用量来确定门冬氨酸洛美沙星粉针剂制备的最佳处方,采用紫外分光光度法来测定门冬氨酸洛美沙星的含量。确定葡萄糖作为赋形剂且主药和赋形剂质量配比为1∶1为最佳的处方,制得的门冬氨酸洛美沙星粉针剂主药含量为标示量99%。设计的门冬氨酸洛美沙星粉针剂处方简单合理,制剂中主药含量符合要求。To prepare and quantitativeey determine of frozen-dried supporting agent are screened based on Lomefloxacin aspartate for injection, the kinds and quantity the external appearance and the quality, and the contont of lomefloxacin aspartate is determined by ultraviolet spectrophotometry. The resuts show that glucose 50% is used as frozen-dried supporting agent. The content of lomefloxacin aspartate is 99% as labelled. The preparation technics is appropriate and the determination method is simple and feasible. The prepared frozen-dried injection is able to meet both the pharmaceutical and clinical requirements.

关 键 词：门冬氨酸洛美沙星 制备 含量测定 

分 类 号：R917[医药卫生—药物分析学]