丙硫异烟胺的热稳定性及其热分解动力学  

Thermal Stability and Kinetics of Thermal Decomposition for Protionamide

作　　者：王韶旭[1] 赵哲[1] 谭志诚[1] 李彦生[1] 童波[2] 史全[2] 李英[1] 

机构地区：[1]大连交通大学环境与化学工程学院,辽宁大连116028 [2]中国科学院大连化学物理研究所材料热化学实验室,辽宁大连116023

出　　处：《物理化学学报》2007年第9期1459-1462,共4页Acta Physico-Chimica Sinica

基　　金：国家自然科学基金(20373072)资助项目

摘　　要：通过热重法研究了抗结核药物丙硫异烟胺的热稳定性,计算了该药物的动力学参数并建立了热分解动力学方程.用Kissinger和Ozawa-Flynn-Wall两种方法计算该药物热分解过程的活化能E_a=54.65 kJ·mol^(-1).用Malek法推断该药物的动力学机理函数及指前因子A,其结果分别为f(α)=α^(0.391)(1-α)^(0.145),InA=13.12.此外,用差热法测定该物质的熔点、摩尔熔化焓和摩尔熔化熵,分别是414.09 K、23.21 kJ·mol^(-1)和56.06 J·mol^(-1)·K^(-1).The thermal stability and the kinetics of thermal decomposition of protionamide were studied by thermogravimetry.Activation energy Ea of thermal decomposition of this substance was obtained to be 54.65 kJ·mo1^-1 by Kissinger method and Ozawa-Flynn-Wall method.Kinetics model function and frequency factor A of protionamide were predicted with the Malek method,which were f（α）=α^0.391（1-α）^0.145 and InA=13.12,respectively.Moreover,melting point,molar enthalpy and entropy of fusion of this compound were determined to be 414.09 K,23.21 kJ·mol^-1,and 56.06 J·mol^-1·K^-1,respectively.

关 键 词：丙硫异烟胺 热分解动力学 热重分析 差热分析 热力学性质 

分 类 号：O621.2[理学—有机化学]