氯诺昔康用于食管癌术后镇痛对IL-2、IL-6、IL-10的影响  

The Effects of Postoperative Analgesia with Lornoxicam on IL-2,IL-6 and IL-10 of Patients with Esophageal Cancer

作　　者：文建忠[1] 杨小敏[1] 郭才桥[1] 熊振凯[1] 

机构地区：[1]江西省肿瘤医院麻醉科,南昌330029

出　　处：《江西医学院学报》2007年第4期44-46,49,共4页Acta Academiae Medicinae Jiangxi

摘　　要：目的观察氯诺昔康用于食管癌术后镇痛对白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)的影响。方法根据术后静脉自控镇痛给药方式不同,将24例食管癌根治术患者随机分为两组,L组(氯诺昔康组,n=12):氯诺昔康40 mg+氟哌利多5 mg;M组(吗啡组,n=12):吗啡40 mg+氟哌利多5 mg。观察患者术后4、244、8 h镇痛评分(visual analogue scale,VAS)及测定外周静脉血IL-2I、L-6I、L-10及TNF-α在诱导前(T1)、术毕(T2)、术后24 h(T3)及术后48 h(T4)的表达水平。结果两组患者术后各时间点VAS评分、两组患者诱导前血浆中IL-2I、L-6I、L-10、TNF-α之间比较及两组患者术后各时间点TNF-α与诱导前比较,无显著性差异(P>0.05);M组IL-2在术后各时间点较术前有显著降低(P<0.05);IL-6I、L-10在术后各时间点较术前则有显著升高(P<0.05);L组IL-2在术后各时间点较术前有显著降低(P<0.05);IL-6I、L-10在术后T2、T3时间点较术前有显著升高(P<0.05);L组较M组IL-10在T4有显著降低(P<0.05)。结论氯诺昔康用于食管癌术后镇痛疗效与吗啡相当,且对免疫功能的影响优于吗啡。Objective To observe the effects of postoperative analgesia with lornoxicam on IL- 2,IL-6 and IL-10 of patients undergoing esophagectomy. Methods Twenty-four patients undergoing esophagectomy were randomly divided into two groups acording to the patients-controlled intravenous analgesia. L group （Lornoxicam group, n=12） ： Lornoxicam 40 mg＋Droperidol 5 mg; M group（Morphine group,n= 12） ： Morphine 40 mg＋Droperidol 5 mg. To observe the VAS （visual analogue scale） of patients at the postoperative time of 4,24,48 h and test the expression levels of plasma IL-2, IL-6, IL-10 and TNF-α before the intubation（T1 ）,extubation（T2 ）and the postoperative time of 24 h（T3）,48 h（T4）. Results There was no significant difference between the two groups in the postoperative VAS and the levels of the preoperative IL-2, IL-6,IL-10 and TNF-α at various time points（P〉0.05）. There was no significant difference between the two groups in the levels of the postoperative TNF-α at various time points compared with the preoperative（P〉0.05）. M group： the levels of the postoperative IL-2 reduced significantly at various time points compared with the preoperative（P〈0.05）, the levels of the postoperative IL-6 IL-10 increased significantly at various time points compared with the preoperative （P〈0. 05）. L group： the levels of the postoperative IL-2 reduced significantly at various time points compared with the preoperative（P〈0.05） ; the levels of the postoperative IL-6,IL-10 increased significantly at the time point of T1, T2 compared with the Preoperative（P〈0.05）. L group compared with M group： the level of the IL-10 reduced significantly at the time point of T1 （P〈0.05）. Conclusion The effect of postoperative analgesia with lornoxicam on the esophagectomy is similar with the morphine, but the effect on the immune function is superior to the morphine.

关 键 词：食管癌 镇痛 氯诺昔康 吗啡 白细胞介素IL-2 白细胞介素-6 白细胞介素-10 

分 类 号：R971.2[医药卫生—药品]