微流控芯片上电驱动在线富集技术的研究进展  

Advances of On-line Enrichment Driven by Electric Fields on Micro-fluidic Chip

作　　者：徐溢[1] 徐平洲[1] 张剑[1] 曹强[1] 温志渝[2] 

机构地区：[1]重庆大学化学化工学院,微系统研究中心重庆400044 [2]重庆大学微系统研究中心,重庆400044

出　　处：《化学通报》2007年第9期655-661,共7页Chemistry

基　　金：国家自然科学基金和(20675089和90307015);科技部863计划项目(2006AA04Z345);国际科技合作项目(2006DFA13510);重庆市自然科学基金重点项目(CSTC;2006BA4012)和(CSTC-2006BB7184)资助

摘　　要：微流控芯片上电驱动在线富集技术是一种有效提高分析效率、检测灵敏度和降低对检测器要求的技术和方法。本文针对目前微流控芯片分析系统中生化样品的预处理问题,对芯片上电驱动在线富集技术进行了分析讨论,介绍了等速电泳、等电聚焦、场放大和介电电泳的样品预富集技术在微流控芯片上的实现与应用,并对每一种技术的原理、特点、存在的问题、近年发展的状况和发展趋势进行了综述。On-line enrichment technique driven by electric fields on micro-fluidic chip was a kind of effective method to improve analytical efficiency, detecting sensitivity and also reducing the request of detector. Aim at the puzzle of biochemical pretreatment in micro-fluidic chip analytical system, on-line enrichment techniques driven by electric fields on micro-fluidic chip, such as isotachophoresis, isoelectric focusing, field amplification and dielectrophoresis, were discussed in detail. The principles, characteristics, problems and current developments of these enrichment techniques were reviewed.

关 键 词：微流控芯片 电驱动在线富集 等速电泳 等电聚焦 场放大 

分 类 号：O658[理学—分析化学]