阿司匹林与糖尿病  

Aspirin and diabetes

作　　者：郭启煜[1] 郝丽云[1] 

机构地区：[1]海军总医院内分泌科,北京100037

出　　处：《国际内分泌代谢杂志》2007年第5期306-309,共4页International Journal of Endocrinology and Metabolism

摘　　要：阿司匹林是环氧合酶抑制剂,具有抗炎、抗风湿作用。许多研究表明,阿司匹林对缓解糖尿病、预防其心血管并发症起一定作用。其可能的作用机制包括抑制血小板和蛋白质糖基化,通过抑制核因子κB抑制蛋白激酶β（IKKβ）增强胰岛素信号的敏感性,保护胰岛β细胞,从而逆转糖尿病动物的高血糖、高胰岛素血症和脂质代谢紊乱。然而由于糖尿病和高血糖状态下存在代谢紊乱,部分糖尿病患者存在阿司匹林抵抗。阿司匹林的主要不良反应是胃黏膜损伤和胃肠道出血。Many reports have demonstrated that aspirin, an inhibitor of cyclooxygenase with anti-inflammation and anti-rheumatism function, has beneficial effects for diabetes and its cardiovascular complications. The possible mechanisms include inhibition of platelet activation and protein glycation, protection of β-cells and increasing sensitivity of insulin signal by inhibiting activity of IκB kinase β（IKKβ）,thus leading to reversal of hyperglycemia, hyperinsulinemia and dyslipidemia in diabetes. However, some diabetic patients show aspirin resistance, which might be associated with metabolic disorders in diabetes and hyperglycemia. Major adverse effects of aspirin therapy are gastric mucosal injury and gastrointestinal hemorrhage.

关 键 词：糖尿病 阿司匹林 心血管疾病 

分 类 号：R587[医药卫生—内分泌] R9[医药卫生—内科学]