舒利通颗粒治疗慢性前列腺炎/盆腔疼痛综合征的临床与实验研究  

Clinical and laboratory research on the effect of Shulitong granules on chronic prostatitis and pelvic pain syndrome

作　　者：江海身[1] 刘春英[2] 凌云[1] 

机构地区：[1]中国人民解放军海军总医院,北京100037 [2]石家庄市第二医院,河北石家庄050051

出　　处：《中国性科学》2007年第9期3-6,共4页Chinese Journal of Human Sexuality

摘　　要：目的:研究舒利通颗粒治疗阴虚湿热夹瘀型慢性前列腺炎的临床疗效,并探讨其机制。方法:用舒利通颗粒治疗80例阴虚湿热夹瘀型慢性前列腺炎3个月,观察临床疗效及治疗前后患者慢性前列腺炎症状评分(NIH-CPSI)变化情况。动物实验研究采用二甲苯、醋酸等致炎剂,观察舒利通颗粒对由此产生的小鼠耳廓肿胀及扭体的镇痛作用、大鼠棉球肉芽肿形成的影响。结果:舒利通颗粒治疗80例阴虚湿热夹瘀型慢性前列腺炎,痊愈14例,显效52例,有效9例,总有效率93·8%。治疗后患者NIH-CPSI评分明显低于治疗前(P<0·01)。实验研究:舒利通颗粒对小鼠醋酸扭体反应次数有显著性降低(P<0·01);舒利通颗粒对二甲苯的致炎作用有显著性减轻(P<0·05);舒利通颗粒对大鼠棉球肉芽肿形成有显著的抑制作用(P<0·01)。结论:舒利通颗粒对阴虚湿热夹瘀型慢性前列腺炎有较好的治疗效果。Objectives： To investigate the therapeutic effect of Shulitong granules on chronic prostatitis and to explore its functioning mechanism. Methods： Shulitong granules were applied to 80 patients with chronic prostatitis for 3 months to observe their effects and to compare the NIH - CPSI changes before and after the treatment. As to laboratory research, Shulitong granules were used to ease pain of auricle swelling in mice and to affect the formation of granuloma in rats. The inflammation of animals was caused by such agents as dimethylbenzene and acetic acid. Results： Clinical observation showed that among 80 cases of chro- nic prostatitis treated with Shulitong, 14 cases recovered, 52 cases improved and 9 cases reacted positively, the overall efficiency rate being 93.8%. NIH - CPSI value after the treatment was significantly lower than that before the treatment（ P 〈 0.01 ）. Laboratory study indicated that Shulitong granules can significantly lower the frequency of body - twisting response in mice caused by acetic acid （P 〈0.01 ） , can have significant anti -inflammatory effect（P 〈0.05 ） , and can significantly inhibit the formation of granuloma in rats（ P 〈 0.01 ）. Conclusion. Shulitong granules have satisfactory therapeutic effects on chronic prostatitis.

关 键 词：慢性前列腺炎 舒利通颗粒 抗炎 消肿 镇痛 

分 类 号：R697.33[医药卫生—泌尿科学]