高压氧治疗新生儿缺氧缺血性脑病对心肌损害保护作用的探讨  

Protective effect of hyperbaric oxygen therapy on cardiac damage in neonat with anoxic ischemic encephalopathy

作　　者：梁淑萍[1] 王长华[1] 黄家红[1] 高国花[1] 

机构地区：[1]华北石油管理局总医院,河北省任丘062552

出　　处：《中华航海医学与高气压医学杂志》2007年第4期216-217,共2页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探讨高压氧治疗新生儿缺氧缺血性脑病(HIE)对心肌损害的保护作用。方法96例缺氧缺血性脑病新生儿分为高压氧治疗组(HBO组)和常规治疗组(CON组),每组48例,两组分别于治疗前后测定QT间期离散度(QTcd)和血清肌酸激酶同工酶(CK-MB)。结果两组治疗前QTcd、CK- MB无明显差异,治疗后HBO组QTcd、CK-MB均较CON组下降,差异具有统计学意义(P<0.05)。结论高压氧治疗HIE对缺氧缺血性心肌损害具有保护作用。Objective To explore the protection of hyperbaric oxygen （HBO） therapy on cardiac damage of anoxia hypoxic ischemic encephalopathy. Methods 96 neonates with hypoxic ischemic encephalopathy （ HIE ） were divided into HBO group and conventional therapy （CON）group, each group included 48 cases. QTcd and CK-MB were measured before and after treatment. Results There was no significant difference in QTcd and CK-MB between two groups before treatment. After therapy, QTcd and CKMB in HBO group were lower than those of CON group （ P 〈 0. 05 ）. Conclusions There were protections for cardiac damage of anoxia hypoxic ischemic encephalopathy by HBO therapy.

关 键 词：高压氧 缺氧缺血性脑病 新生儿 心肌损害 QT间期离散度 肌酸激酶同工酶 

分 类 号：R459.6[医药卫生—治疗学] R722.1[医药卫生—临床医学]