高压氧在治疗急性脑梗死中的抗自由基作用  

Protective effect of hyperbaric oxygen therapy on free radical reaction after acute cerebral infarction

作　　者：陆磊[1] 张进[1] 孙晓江[1] 施弘[1] 蒋青青[1] 薛波[1] 

机构地区：[1]上海交通大学附属第六人民医院神经内科,上海200233

出　　处：《中华航海医学与高气压医学杂志》2007年第4期239-242,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探讨高压氧治疗急性脑梗死的疗效和抗自由基作用。方法100例首次发病的急性前循环脑梗死患者,分成高压氧治疗组和常规治疗组,每组50例,高压氧治疗组在常规治疗组基础上加用高压氧治疗。治疗前和治疗后第14、28、90天进行神经功能缺损评分(NIHSS)和日常生活活动能力评分(ADL);治疗前和治疗后第3、7天检测NO、红细胞超氧化物歧化酶(E-SOD)、过氧化脂质(LPO)、过氧化氢酶(E-CAT)、谷胱甘肽过氧化物酶(E-GSH-PX)水平。结果与常规治疗组比较,在治疗后的第14、28、90天,高压氧治疗组NIHSS和ADL均有显著改善(P<0。05),无严重并发症;在治疗后的第3、7天,高压氧治疗组NO、LPO等指标明显下降(P<0.05),E-SOD、E-CAT、E-GSH-PX等指标明显上升(P<0.05)。结论高压氧在治疗急性前循环脑梗死中具有抗自由基作用,能改善患者神经功能缺损,提高患者日常生活活动能力,是一种安全的、有效的方法。Objective To explore curative effect and protection of hyperbaric oxygen （HBO） therapy on free radical reaction after acute cerebral infarction. Methods One hundred patients with first-time acute anterior cerebral infarction were assigned into HBO therapy group and conventional therapy group. Patients in the routine treatment group （n = 50） were treated with clinical routine treatment only, whereas those in the HBO group （n = 50） were treated with HBO therapy combined with clinical routine treatment. The therapeutic efficacy were evaluated by scores of neurologic impairment（NIHSS） and activities of daily living （ADL） before treatment and on 14,28,90 days after treatment. At the same time, levels of nitrogen monoxidum （ NO）, erythrocuprein （ E-SOD）, lactoperoxidase （ LPO）, catalase （E-CAT） and glutathione-peroxidase （E-GSH-PX） were detected before treatment and on 3,14 days after treatment. Results There were significant improvements in NIHSS and ADL of the HBO group compared with those of the routine group at on 14,28,90 days after treatment （P 〈 0.05 ）and no serious adverse effects. The index of NO,LPO in the HBO group decreased（P 〈 0.05） while the levels of E-SOD, E-CAT. E-GSH-PX increased obviously （ P 〈 0.05 ）. Conclusions HBO therapy may protect free radical reaction after acute cerebral infarction with improving neurologic impairment and ADL, it would promise as a safe and effective treatment.

关 键 词：高压氧 脑梗死 自由基 

分 类 号：R459.6[医药卫生—治疗学]