^(99)Tc^m-HL91肺显像与非小细胞肺癌恶性程度、MVD表达的相关性  

Relationship among ^(99)Tc^m-HL91 imaging and NSCLC malignant grade, MVD expression

作　　者：闫新慧[1] 刘保平[2] 武新宇[1] 谢新立[2] 

机构地区：[1]河南省人民医院核医学科,河南郑州450003 [2]郑州大学第一附属医院核医学科,河南郑州450052

出　　处：《中国医学影像技术》2007年第8期1229-1232,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨99Tcm-HL91(4,9-二氮-2,3,10,10-四甲基十二烷-2,11-二酮肟)显像与肺癌恶性程度、肿瘤微血管密度(MVD)表达的关系。方法35例非小细胞肺癌患者,注射99Tcm-HL91,4h后进行胸部前后位、后前位平面及断层显像,利用感兴趣区技术,计算肿瘤与对侧(T/N)正常组织的放射性比值。所有患者均行细胞学检查,将标本做HE染色、免疫组织化学染色。结果99Tcm-HL91平面显像:35例非小细胞肺癌患者中的30例显像阳性;断层显像:33例显像阳性。定量分析:断层像4h的T/N比值显著高于平面像的T/N比值(t=10.619,P=0.000);HL91显像的T/N比值与肺癌细胞恶性程度相关(r=0.626,P=0.000)。癌巢及癌细胞密集区的MVD显著少于癌周区及增生活跃区。MVD表达在非小细胞肺癌细胞恶性程度分级间有显著差异(F=8.49,P=0.01)。HL91显像的T/N比值与MVD表达高度相关(r=0.721~0.862,平均r=0.791,P<0.05)。结论99Tcm-HL91显像的T/N比值与非小细胞肺癌细胞恶性程度分级呈中度相关,与MVD表达呈高度相关。99Tcm-HL91显像可以作为一种无创伤的检查方法,评价肿瘤分级,并对NSCLC生物学行为的了解和预后判定有着重要的意义。　Objective To evaluate the ability of ^99Tc^m-HL91 imaging in characterising the non-small-cell lung cancer （NSCLC） malignant grades and the relation between ^99Tc^m-HL91 （4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dionedioxime） imaging and MVD expression by comparing imaging with HE、immunohistochemistry staining in human NSCLC. Methods Thirty-five patients,with NSCLC, performed SPECT and anteroposterior、posteroanterior chest planar imagings at 4 hour after injection of ^99Tc^m-HL91. ROIs were drawn in imagings of tumor and symmetry in lung planar scan, and the radioactivity ratios tumor-to-normal tissue were calculated. All patients were operated and the samples were stained for immunohistochemistry. Results Planar imaging： ^99Tc^m-HL91 was showed visible uptake in 30 out of 35 NSCLC patients. SPECT imaging： 33 out of 35 were positive. Tumor-to-normal tissue ratios （T/N）, the difference of T/N between between planar imaging and SPECT was significant （t=10.619,P=0.000）. And uptake of ^99Tc^m-HL91 was related to the malignancy of the cancer cell （r=0.626,P=0.000）. MVD was higher expressed at the periphery of tumor than in the middle of tumor. The difference of expressive intensity among the malignancy of cancer cell was significant （F=8.49,P=0.01）. Uptake of ^99Tc^m-HL91 was strongly correlated to the expressive intensity of MVD （r=0.721-0.862,mean r=0.791,P〈0.05）. Conclusion Uptake of HL91 and expression of MVD were strongly correlated to the malignancy of the cancer cell. HL91 imaging is an important atraumatic method in predicting the malignancy of the cancer cell and the therapeutic effect.

关 键 词：非小细胞肺癌 核素显像 HL91 MVD CD34 

分 类 号：R817.4[医药卫生—影像医学与核医学] R734.2[医药卫生—放射医学]