电化学疗法用于小鼠S-180治疗的研究  

The Research on the Treatment of Mice Sarcomas with Electrochemotherapy(ECT)

作　　者：童峥嵘[1] 龚元元[1] 徐宝强[1] 孙云[1] 赵军发[1] 袁其平[1] 孙倩[2] 王世贤[3] 

机构地区：[1]天津理工大学电子信息与通信工程学院 [2]天津市人民医院,天津300121 [3]天津市医药科学研究所,天津300070

出　　处：《生命科学仪器》2007年第8期46-49,共4页Life Science Instruments

基　　金：国家自然科学基金项目项目名称:基因电导入技术的研究与应用项目编号:60451001

摘　　要：电化学疗法是将电穿孔与化学药物相结合治疗肿瘤的一种新方法,电穿孔可通过脉冲电场瞬时提高细胞膜的通透性使药物等外源物质进入细胞,增强细胞对药物的吸收能力,从而提高治疗肿瘤的效果。我们采用LN-101基因脉冲导入仪及配套的针电极,通过电化学疗法对接种有S-180的小鼠进行对比实验。结果应用抗癌药物博莱霉素(BLM)的电化学疗法(ECT)组的抑瘤率为70.4%,与传统的治疗方法相比抑瘤率显著提高。Electrochemotherapy （ECT） is a new efficient approach which treats tumor by electroporation and chemotherapeutic agents. Electroporation can deliver exogenous molecules such as drugs into cell by pulsed electric fields through a temporary increase in cell membrane permeability. It results in much higher uptake of the drugs and better effect of antitumoral treatment. We have performed the experiments on mice inoculated S-180 using gene pulse ransfection apparatus LN-101 and needle electrodes combined with antitumor drugs. Inhibitory rates of ECT with antitumor drugs Bleomycin（BLM） is 70.4%, and is enhanced significantly in contrast to other methods in the experiments.

关 键 词：电化学疗法 电穿孔 肿瘤治疗 针电极 

分 类 号：Q959.837[生物学—动物学]