NICU新生儿败血症心肌损害与出生状况的相关性研究  

A clinical study on the myocardial injury in neonatal septicemia and its relationship with birth status.

作　　者：徐灵敏[1] 张展[2] 贾莉婷[2] 栾斌[1] 

机构地区：[1]郑州大学第三附属医院儿内科,河南郑州450052 [2]郑州大学第三附属医院检验科,河南郑州450052

出　　处：《中国实用儿科杂志》2007年第9期666-668,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的研究新生儿败血症心肌损害的发生与其出生时状况的相关关系,以改善新生儿败血症的预后。方法采用前瞻性临床观察研究方法,对郑州大学第三附属医院NICU2005-11-15—2006-05-31收治的112例败血症新生儿心肌损害的发生与其出生时胎龄、体重、性别、产式及有无窒息史等状况的关系进行了相关性分析。结果112例患儿中发生心肌损害者57例(50.9%)。23例早产儿心肌损害的发生率为78.3%,显著高于足月儿(43.4%),早产与新生儿败血症心肌损害的发生有显著的正相关性(r=0.288,P<0.05);28例低出生体重儿心肌损害的发生率为67.9%,显著高于正常出生体重儿(45.2%),低出生体重与新生儿败血症心肌损害的发生有显著的正相关性(r=0.196,P<0.05);新生儿败血症合并窒息者34例,心肌损害的发生率为85.3%,显著高于无窒息者(35.9%),窒息与新生儿败血症心肌损害的发生有显著的正相关性(r=0.454,P<0.05)。而不同性别及分娩方式对患婴心肌损害的发生率无影响。结论早产、低体重、窒息是新生儿败血症发生心肌损害的3个高危因素,对于这些新生儿发生败血症时,更要关注其心肌损害的发生以降低病死率。Objective To improve the prognosis of neonatal septicemia,a clinical study was conducted to investigate the myocardial injury in neonatal septicemia and its relationship with birth status. Methods In a prospective, observational study,112 cases of neonatal septicemia admitted to our NICN from 2005-11-15---2006-5-31 were recruited in the study. Design Excel form ,record each selection of general circumstance and birth status, including gender, gestation age, birth weight, delivery mode,perinatal asphyxia, and analyze the correlations between these items and the myocardial injury. Resuits All together,57 cases had myocardial injury in the 112 cases, the myocardial injury ratio being 50. 9% in the study. The myocardial injury ratio was 78.3% in 23 preterm infants,significantly higher than that in term infants（43.4% ） ; there was a positive correlation between preterm and myocardial injury in neonatal septicemia （ r = 0. 288, P 〈 0. 05 ）. The myocardial injury ratio was 67. 9% in 28 low birth weight infants ,significantly higher than that in normal birth weight infants（45.2% ） ;there was a positive correlation between low birth weight and myocardial injury in neonatal septicemia （ r =0. 196, P 〈0. 05）. There were 34 cases companying perinatal asphyxia in the study. The myocardial injury ratio was 85.3% in the asphyxia infants, significantly higher than that in non-asphyxia infants （35.9%） ;there was a positive correlation between asphyxia and myocardial injury in neonatal septicemia （ r = 0. 454, P 〈 0. 05 ）. The gender and delivery mode were not associated with the myocardial injury in these study. Conclusion Preterm,low birth weight and asphyxia are three risk factors for myocardial injury in neonatal septicemia. In order to reduce the mortality of neonates, we should pay more attention to these infants with septicemia.

关 键 词：婴儿 新生 败血症 早产 低体重 窒息 

分 类 号：R72[医药卫生—儿科]