全垂体功能减低男性患儿性激素变化及治疗  

Analysis of delayed gonadal development and therapy in panhypopituitarism.

作　　者：李桂梅[1] 李西霞[1] 谢蓉蓉[1] 

机构地区：[1]山东大学山东省立医院儿科,山东济南250021

出　　处：《中国实用儿科杂志》2007年第9期701-703,共3页Chinese Journal of Practical Pediatrics

基　　金：山东省人事厅2006年度留学回国人员科技活动择优资助课题(项目编号2006178)

摘　　要：目的探讨全垂体功能减低男性患儿性激素的改变特点,以适时进行性激素补充治疗(HRT),改善男性性征。方法测定1999-09—2006-03因生长迟缓在山东省医院就诊的44例全垂体功能减低的10岁以上男性患儿性激素,并与44例年龄匹配的对照组进行比较;观察两组儿童性激素水平差异。结果44例全垂体功能减低患儿与对照组儿童性激素比较显示,观察组促卵泡激素(FSH)、促黄体生成激素(LH)、睾酮(To)均显著低于对照组,且44例患儿(100%)均有此三项降低;雌激素(E2)、泌乳素(PRL)均显著高于对照组。其中26例(59%)有E2升高,27例(61%)有PRL升高。此可解释男性垂体功能减低患儿女性体态、外生殖器发育不良及乳房发育。结论全垂体功能减低患儿常伴有性发育不良,早期诊断、及时有效替代治疗非常必要。Objective To discuss the gonad function and.hormone replacement therapy（HRT） in panhypopituitarism. Methods The serum levels of follicle stimulating hormone （ FSH ） , luteinizing hormone （ LH ） , prolactin （PRL） , testosterone （ To ） , and estradiol （ E2 ） were measured in 44 male patients with multiple pituitary hormone deficiency （ MPHD ） older than 10 years from Sep. 1999 to Mar. 2006,and compare with 44 ageand sex-matched normal children. Results The serum FSH,LH,To levels were significantly decreased （ P 〈 0. 001 ） and E2 and PRL were significantly increased （ P 〈0. 001 ） in 44 male patients older than 10 years when compared with 44 age- and sex-matched normal children. Conclusion Patients with panhypopituitarism are often associated with abnormal sex hormorne levels and delayed gonadal development; hormone replacement therapy（HRT） should be start promptly.

关 键 词：全垂体功能减低症 儿童 性腺功能 激素替代治疗 

分 类 号：R72[医药卫生—儿科]