拳参正丁醇提取物对豚鼠离体左心房兴奋性及功能性不应期的影响  

The Effect of PBNA on Excitability and FRP of Excised Guinea Pig Pulmonary Atrium

作　　者：李良东[1] 欧阳娟[1] 程洁[1] 黄志华[1] 叶和杨[1] 曾靖[1] 

机构地区：[1]赣南医学院,江西赣州341000

出　　处：《时珍国医国药》2007年第9期2081-2082,共2页Lishizhen Medicine and Materia Medica Research

基　　金：江西省教育厅2006年度科技计划项目(No.赣教技字[2006]252)

摘　　要：目的观察拳参正丁醇提取物对豚鼠离体左心房兴奋性及功能性不应期的影响,并探讨其作用机制。方法采用豚鼠离体左心房测定拳参正丁醇提取物对其强度-时间曲线及功能性不应期的影响。结果拳参正丁醇提取物可使豚鼠离体左心房强度-时间曲线上移,功能性不应期缩短,且有明显的剂量依赖性。结论拳参正丁醇提取物可明显降低左心房的兴奋性,缩短功能性不应期,且有明显的剂量依赖性。其机制可能通过抑制心肌细胞膜电压依赖性钠通道及促进3相K^+外流作用有关。Objective To observe the effect of Polygonum Bistorla＇s n - Butyl alcohol extract （PBNA） on excitability and functional refractory period （FRP） of excised guinea pig pulmonary atrium and to discuss its mechanism. Methods The effect of PBNA on excised guinea pig pulmonary atrium was investigated by intensity - time curve and FRP. Results PBNA upper - shifted intensity- time curve and shortened FRP on excised pulmonary atrium which was in proportion with the extract ＂s dosage. Conclusion PBNA has an effect of reducing excitability and shortening FRP of excised pulmonary atrium in a manner of dosage-dependent. It may work through inhibiting membrane voltage-dependent Na^＋ channel and promoting an outflow K^＋ with cardiac muscle cells.

关 键 词：拳参正丁醇提取物 左心房 兴奋性 功能性不应期 

分 类 号：R285.5[医药卫生—中药学]