^(59)Fe标记的纳米颗粒物从大鼠肺部的渗透过程  

Permeating process of nanoparticles labeled by ^(59)Fe in rat lung

作　　者：梁峰[1] 李超[2] 赵金镯[3] 蒋蓉芳[3] 林俊[1] 刘卫[1] 金婵[1] 宋伟民[3] 范我[2] 张桂林[1] 李燕[1] 

机构地区：[1]中国科学院上海应用物理研究所 [2]苏州大学放射医学院和公共卫生学院,苏州215123 [3]复旦大学公共卫生学院,上海200032

出　　处：《核技术》2007年第9期763-767,共5页Nuclear Techniques

基　　金：国家自然科学基金委重大项目(10490182);中国科学院知识创新工程重要方向性项目(KJCX3.SYW.N3)的资助

摘　　要：利用放射性同位素示踪技术研究超细颗粒物四氧化三铁模拟不溶性大气超细颗粒物对高血压模型大鼠的作用,测定不同时间点血液及其他器官的放射性分布,研究超细颗粒物在肺部的清除规律和进入体内的代谢途径。实验发现,无论是高血压动物还是正常动物,超细颗粒物能通过肺部进入血液,然后进入肝脏参与体内代谢,最后由肠道排出体外。高血压实验组超细颗粒物通过肺部进入血液明显快于对照组,但高血压组对超细颗粒物的排泄明显要慢于对照组。上述结果表明,由于不溶性超细颗粒物更易通过肺部进入体内又比较难于排除出体外的原因,超细颗粒物对患有心血管疾病(如高血压)的病人比正常人群有着更大的危害,患有心血管疾病的人群可能是大气颗粒物污染的易感人群。In order to investigate the adverse impact of hypertension SHR rats caused by simulated particle matter （nano ferric oxide） with radioactivity isotope tracer techniques was researched. By measured the radioactivity intensity in different tissues in different time point, we got the regular pattern of scavenging particles from pulmonary and the metabolism of the particles in a rat. The ultrafine particles can transport from the pulmonary to blood, then participated metabolism and expelled out of the body by feces in both hypertension rats and normal rats. The speed of unltrafine particulars transporting to blood is faster than the normal ones and expelled through feces in hypertension animals are less than those in normal rats. In conclusion, the ultrafine particles are more harmful to hypertension patients because the particles can easily transport from lung to blood and be hardly scavenged from body through feces, so the hypertension patients may be the sensitive group by ultrafine particle in the atmosphere.

关 键 词：高血压 纳米颗粒物 放射性同位素示踪 

分 类 号：R122[医药卫生—环境卫生学]